Endothelial Dysfunction: From Pathophysiology to Novel Therapeutic Approaches

• Autore: Jeon Byeong Hwa
• Pubblicazione: Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022
• Descrizione fisica: 1 online resource (368 p.)
• Soggetto topico: Biotechnology; Technology: general issues
• Soggetto non controllato: ADMA; aerobic exercise; aldehyde dehydrogenase-2; angiogenesis; APE1/Ref-1; ApoE knockout mouse; arginine; arginine paradox; atherosclerosis; atorvastatin; BH4; blood pressure; cardiovascular disease; cardiovascular diseases; cardiovascular risk factors; chronic kidney disease; chronic venous insufficiency; CKD; compound 9; COVID-19; CV risk; diabetes; dietary supplements; dyslipidemia; electronegative LDL; electronegative low-density lipoprotein; EndoMT; endothelial cell; endothelial cell dysfunction; endothelial cells; endothelial disfunction; endothelial dysfunction; endothelial to mesenchymal transition; endothelium; eNOS uncoupling; epigenetic factors; epigenetics; essential hypertension; galectin-3; glycated HDL; glycated LDL; glycated lipoproteins; glycolysis; healing; heart failure; HIF-1α; high-fat diets; hyperglycemia; hyperphosphatemia; hypertension; inflammageing; inflammation; insulin resistance; ischemia; L-arginine; L5 LDL; LDL(-); LDL(−); lectin-like oxLDL receptor-1; low-level laser therapy; LOX-1; lung disease; macrophage polarity; macrophages; metabolism; metformin; molecular mechanisms; MRI (magnetic resonance imaging); myocardial infarction; n/a; NADPH; nargenicin A1; neurovascular disease; neutrophil/lymphocyte ratio; nitric oxide; oxidative stress; oxidized LDL; oxLDL; pathological angiogenesis; PCSK9; peripheral artery disease; phototherapy; plaque burden; prolyl oligopeptidase (POP); pulmonary fibrosis; pulmonary hypertension; serological biomarkers; serum γ-glutamyltransferase; subcellular localization; TGF-β; therapeutic approaches; tumor microenvironment; uremic toxins; vascular calcification; vascular disease; vascular inflammation; vascular smooth muscle cells; vasoactive factors; VCAM-1; VEGF; VEGFR2; VSMCs
• Persona (resp. second.): JeonByeong Hwa
• Sommario/riassunto: Dear colleagues, This Special Issue, "Endothelial Dysfunction: From Pathophysiology to Novel Therapeutic Approaches", focuses on the pathophysiology of endothelial dysfunction, new biomarkers for endothelial dysfunction related to cardiovascular disorders or tumors, and novel therapeutic approaches for endothelial dysfunctions. Vascular endothelium is an active tissue and plays a crucial role in the maintenance of vascular homeostasis. Chronic exposure to risk factors, such as hypertension, high cholesterolemia, or oxidative stress, induces endothelial dysfunctions and results in a loss of endothelial integrity, smooth muscle cell proliferation, and macrophage recruitment. The pathophysiology of endothelial dysfunction (ED) is complex and multi-factorial factors are involved, such as oxidative stress or chronic inflammation. The primary prevention of cardiovascular risk factors and endothelial dysfunctions, as well as the early detection of or molecular imaging techniques for endothelial dysfunction, helps to prevent the development of cardiovascular disorders. Novel therapeutic approaches or drug delivery systems for endothelial dysfunctions have had promising beneficial effects in preclinical or clinical levels by affecting the progression of atherosclerotic changes, tumor angiogenesis, and host-immune reactions near tumor environments.
• Altri titoli varianti: Endothelial Dysfunction
• Titolo autorizzato: Endothelial Dysfunction: From Pathophysiology to Novel Therapeutic Approaches
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910566471803321
• Lo trovi qui: Univ. Federico II