05889nam 2201597z- 450 991056647180332120220506(CKB)5680000000037662(oapen)https://directory.doabooks.org/handle/20.500.12854/81021(oapen)doab81021(EXLCZ)99568000000003766220202205d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierEndothelial Dysfunction: From Pathophysiology to Novel Therapeutic ApproachesBaselMDPI - Multidisciplinary Digital Publishing Institute20221 online resource (368 p.)3-0365-3036-3 3-0365-3037-1 Dear colleagues, This Special Issue, "Endothelial Dysfunction: From Pathophysiology to Novel Therapeutic Approaches", focuses on the pathophysiology of endothelial dysfunction, new biomarkers for endothelial dysfunction related to cardiovascular disorders or tumors, and novel therapeutic approaches for endothelial dysfunctions. Vascular endothelium is an active tissue and plays a crucial role in the maintenance of vascular homeostasis. Chronic exposure to risk factors, such as hypertension, high cholesterolemia, or oxidative stress, induces endothelial dysfunctions and results in a loss of endothelial integrity, smooth muscle cell proliferation, and macrophage recruitment. The pathophysiology of endothelial dysfunction (ED) is complex and multi-factorial factors are involved, such as oxidative stress or chronic inflammation. The primary prevention of cardiovascular risk factors and endothelial dysfunctions, as well as the early detection of or molecular imaging techniques for endothelial dysfunction, helps to prevent the development of cardiovascular disorders. Novel therapeutic approaches or drug delivery systems for endothelial dysfunctions have had promising beneficial effects in preclinical or clinical levels by affecting the progression of atherosclerotic changes, tumor angiogenesis, and host-immune reactions near tumor environments.Endothelial DysfunctionBiotechnologybicsscTechnology: general issuesbicsscADMAaerobic exercisealdehyde dehydrogenase-2angiogenesisAPE1/Ref-1ApoE knockout mouseargininearginine paradoxatherosclerosisatorvastatinBH4blood pressurecardiovascular diseasecardiovascular diseasescardiovascular risk factorschronic kidney diseasechronic venous insufficiencyCKDcompound 9COVID-19CV riskdiabetesdietary supplementsdyslipidemiaelectronegative LDLelectronegative low-density lipoproteinEndoMTendothelial cellendothelial cell dysfunctionendothelial cellsendothelial disfunctionendothelial dysfunctionendothelial to mesenchymal transitionendotheliumeNOS uncouplingepigenetic factorsepigeneticsessential hypertensiongalectin-3glycated HDLglycated LDLglycated lipoproteinsglycolysishealingheart failureHIF-1αhigh-fat dietshyperglycemiahyperphosphatemiahypertensioninflammageinginflammationinsulin resistanceischemiaL-arginineL5 LDLLDL(-)LDL(−)lectin-like oxLDL receptor-1low-level laser therapyLOX-1lung diseasemacrophage polaritymacrophagesmetabolismmetforminmolecular mechanismsMRI (magnetic resonance imaging)myocardial infarctionn/aNADPHnargenicin A1neurovascular diseaseneutrophil/lymphocyte rationitric oxideoxidative stressoxidized LDLoxLDLpathological angiogenesisPCSK9peripheral artery diseasephototherapyplaque burdenprolyl oligopeptidase (POP)pulmonary fibrosispulmonary hypertensionserological biomarkersserum γ-glutamyltransferasesubcellular localizationTGF-βtherapeutic approachestumor microenvironmenturemic toxinsvascular calcificationvascular diseasevascular inflammationvascular smooth muscle cellsvasoactive factorsVCAM-1VEGFVEGFR2VSMCsBiotechnologyTechnology: general issuesJeon Byeong Hwaedt1319556Jeon Byeong HwaothBOOK9910566471803321Endothelial Dysfunction: From Pathophysiology to Novel Therapeutic Approaches3033962UNINA04492nam 22011293a 450 991034666600332120250203235425.09783039213009303921300810.3390/books978-3-03921-300-9(CKB)4920000000095007(oapen)https://directory.doabooks.org/handle/20.500.12854/57735(ScCtBLL)f780192b-201d-4ad9-9ed3-cc5298785cdc(OCoLC)1126165381(oapen)doab57735(EXLCZ)99492000000009500720250203i20192019 uu engurmn|---annantxtrdacontentcrdamediacrrdacarrierRecent Advances in Hydro- and BiohydrometallurgyKostas A. KomnitsasMDPI - Multidisciplinary Digital Publishing Institute2019Basel, Switzerland :MDPI,2019.1 electronic resource (212 p.)9783039212996 3039212990 This Special Issue of Minerals presents recent, select studies that highlight advances in the fields of hydro- and biohydrometallurgy. It aims to attract the interest of readers and especially of young scientists and students in this fascinating scientific discipline. The topics addressed include the following:• Stirred reactor and heap leaching of laterites (limonitic and saprolitic), as well as iron control during atmospheric acid leaching;• Leaching of a typical porphyry copper sulfide deposit from Antofagasta, Chile, using chloride-ferrous solutions;• Leaching of chalcopyrite ores with various leaching media;• Leaching of white metal from a Teniente converter in NaCl-H2SO4 media; • Study of the galvanic effect of pyrite and arsenopyrite during the leaching of gold ores;• Leaching of marine nodules in the presence of reducing agents to extract Mn;• Bioleaching of gold ores in the presence of iodide-oxidizing bacteria;• A two-step sequential leaching process, involving bioleaching and chemical leaching, to treat apatite ores containing P and U impurities;• Bioreductive dissolution of iron minerals present in monazite in stirred reactors using Acidithiobacillus (A.) species;• Heap leaching of municipal solid waste incineration bottom ash (MSWI BA) for the recovery of Zn and Cu.History of engineering and technologybicssccounter-current leachingmetal extractionslaglow-grade saprolitic lateriteagglomerationbioleachingwhite metalprecipitationiodideseawaterreducing agentchloridechalcopyritepyrite-arsenopyrite galvanic pairfrontier orbital methodsacid mediabottom ashphosphorusmanganese noduleswaste reusegalvanic effectgold diiodidemunicipal solid waste incinerationjarositecolumn leachingsecondary miningiodide-oxidizing bacterialeachingprimary sulfide copperheap leachingelectrochemicaloptimization of parameterschloride ionreductive mineral dissolutiontailingscuringacid leachingsecondary productsuraniumferric ionAcidithiobacilluslimonitic lateritesiron reductionfluorapatitenitrategoldphosphate mineralpurificationiodinenickelsodium sulfitepregnant leach solutioncopper sulfidesulphuric acidlateritesREEpretreatmenttriiodidelateriteHistory of engineering and technologyKomnitsas Kostas A1320429ScCtBLLScCtBLLBOOK9910346666003321Recent Advances in Hydro- and Biohydrometallurgy3034296UNINA