Drug Absorption Studies: In Situ, In Vitro and In Silico Models

• Autore: Song Im-Sook
• Pubblicazione: Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021
• Descrizione fisica: 1 online resource (171 p.)
• Soggetto topico: Manufacturing industries; Medicine and Nursing
• Soggetto non controllato: acetaminophen-induced hepatotoxicity; amorphous solid dispersion; BCS drug classification; bioavailability; biomedical drug; breast cancer resistance protein; candesartan Cilexetil; catabolism disorder; chitosan; cinnarizine; D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS); dissolution profiles; drug-phytochemical interaction; endocytosis; enoxaparin; enzyme; extra virgin olive oil; hepatic metabolism; hydrogel; in vivo-in vitro correlation; intestinal absorption; intestinal permeability; kinetics; l-phenylalanine ammonia-lyase; lipid-based drug delivery system; lipid-polymer hybrid nanoparticles; lipolysis; lipolysis-permeation; liver distribution; LY335979; meloxicam; metabolism; microsphere; mixed inhibition; naftidrofuryl oxalate; nanocrystals; nasal administration; non-sink condition; oral; oral mucositis; P-glycoprotein; permeability; PermeaPad; pH-modulation; pharmaceutical availability; phenolic compounds; phenylketonuria; poorly soluble drugs; PVPK30; quercetin; rebamipide; repaglinide; secoiridoids; silymarin; solubility; solubility-permeability interplay; solubilizer additive; spray drying; spray-drying; unstirred water layer; WK-X-34
• Persona (resp. second.): SongIm-Sook
• Sommario/riassunto: This Book serves to highlight the mechanisms related to the low intestinal drug absorption, the strategies to overcome the obstacles or intestinal drug absorption, and in situ, in vitro, and in silico methodologies to predict to intestinal drug absorption. This Book presents a series of drug absorption studies and related technologies that predict intestinal permeation of drugs that govern the pharmacokinetic features of therapeutic drugs. It also contains the mechanistic understanding regarding the first-pass metabolism and intestinal efflux that modulate the pharmacokinetics of drug and suggest the formulation strategies to enhance the bioavailability of investigated drugs.
• Altri titoli varianti: Drug Absorption Studies
• Titolo autorizzato: Drug Absorption Studies: In Situ, In Vitro and In Silico Models
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910557689203321
• Lo trovi qui: Univ. Federico II