03988nam 2201105z- 450 991055768920332120220111(CKB)5400000000044639(oapen)https://directory.doabooks.org/handle/20.500.12854/77071(oapen)doab77071(EXLCZ)99540000000004463920202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierDrug Absorption Studies: In Situ, In Vitro and In Silico ModelsBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (171 p.)3-0365-2461-4 3-0365-2460-6 This Book serves to highlight the mechanisms related to the low intestinal drug absorption, the strategies to overcome the obstacles or intestinal drug absorption, and in situ, in vitro, and in silico methodologies to predict to intestinal drug absorption. This Book presents a series of drug absorption studies and related technologies that predict intestinal permeation of drugs that govern the pharmacokinetic features of therapeutic drugs. It also contains the mechanistic understanding regarding the first-pass metabolism and intestinal efflux that modulate the pharmacokinetics of drug and suggest the formulation strategies to enhance the bioavailability of investigated drugs.Drug Absorption StudiesManufacturing industriesbicsscMedicine and Nursingbicsscacetaminophen-induced hepatotoxicityamorphous solid dispersionBCS drug classificationbioavailabilitybiomedical drugbreast cancer resistance proteincandesartan Cilexetilcatabolism disorderchitosancinnarizineD-α-Tocopherol polyethylene glycol 1000 succinate (TPGS)dissolution profilesdrug-phytochemical interactionendocytosisenoxaparinenzymeextra virgin olive oilhepatic metabolismhydrogelin vivo-in vitro correlationintestinal absorptionintestinal permeabilitykineticsl-phenylalanine ammonia-lyaselipid-based drug delivery systemlipid-polymer hybrid nanoparticleslipolysislipolysis-permeationliver distributionLY335979meloxicammetabolismmicrospheremixed inhibitionnaftidrofuryl oxalatenanocrystalsnasal administrationnon-sink conditionoraloral mucositisP-glycoproteinpermeabilityPermeaPadpH-modulationpharmaceutical availabilityphenolic compoundsphenylketonuriapoorly soluble drugsPVPK30quercetinrebamipiderepaglinidesecoiridoidssilymarinsolubilitysolubility-permeability interplaysolubilizer additivespray dryingspray-dryingunstirred water layerWK-X-34Manufacturing industriesMedicine and NursingSong Im-Sookedt1302990Song Im-SookothBOOK9910557689203321Drug Absorption Studies: In Situ, In Vitro and In Silico Models3026813UNINA