03955nam 2201093z- 450 991055768920332120231214133312.0(CKB)5400000000044639(oapen)https://directory.doabooks.org/handle/20.500.12854/77071(EXLCZ)99540000000004463920202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierDrug Absorption Studies: In Situ, In Vitro and In Silico ModelsBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 electronic resource (171 p.)3-0365-2461-4 3-0365-2460-6 This Book serves to highlight the mechanisms related to the low intestinal drug absorption, the strategies to overcome the obstacles or intestinal drug absorption, and in situ, in vitro, and in silico methodologies to predict to intestinal drug absorption. This Book presents a series of drug absorption studies and related technologies that predict intestinal permeation of drugs that govern the pharmacokinetic features of therapeutic drugs. It also contains the mechanistic understanding regarding the first-pass metabolism and intestinal efflux that modulate the pharmacokinetics of drug and suggest the formulation strategies to enhance the bioavailability of investigated drugs.Drug Absorption StudiesMedicinebicsscPharmaceutical industriesbicsscrebamipidenanocrystalsoral mucositishydrogelendocytosisenoxaparinlipid–polymer hybrid nanoparticlesoralintestinal absorptionnaftidrofuryl oxalatesolubilitypermeabilitydissolution profilespharmaceutical availabilityBCS drug classificationnon-sink conditionsolubility–permeability interplayunstirred water layerpoorly soluble drugssolubilizer additivephenylketonurial-phenylalanine ammonia-lyaseenzymekineticscatabolism disorderbiomedical drugP-glycoproteinbreast cancer resistance proteinLY335979WK-X-34in vivo–in vitro correlationlipolysis-permeationlipid-based drug delivery systemPermeaPadcinnarizinelipolysisamorphous solid dispersioncandesartan CilexetilPVPK30pH-modulationspray dryingbioavailabilitynasal administrationspray-dryingchitosanmicrospheremeloxicamsilymarinD-α-Tocopherol polyethylene glycol 1000 succinate (TPGS)liver distributionacetaminophen-induced hepatotoxicityextra virgin olive oilsecoiridoidsmetabolismphenolic compoundsintestinal permeabilitydrug-phytochemical interactionhepatic metabolismmixed inhibitionquercetinrepaglinideMedicinePharmaceutical industriesSong Im-Sookedt1302990Song Im-SookothBOOK9910557689203321Drug Absorption Studies: In Situ, In Vitro and In Silico Models3026813UNINA