LEADER 03988nam 2201105z- 450 001 9910557689203321 005 20220111 035 $a(CKB)5400000000044639 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/77071 035 $a(oapen)doab77071 035 $a(EXLCZ)995400000000044639 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aDrug Absorption Studies: In Situ, In Vitro and In Silico Models 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 online resource (171 p.) 311 08$a3-0365-2461-4 311 08$a3-0365-2460-6 330 $aThis Book serves to highlight the mechanisms related to the low intestinal drug absorption, the strategies to overcome the obstacles or intestinal drug absorption, and in situ, in vitro, and in silico methodologies to predict to intestinal drug absorption. This Book presents a series of drug absorption studies and related technologies that predict intestinal permeation of drugs that govern the pharmacokinetic features of therapeutic drugs. It also contains the mechanistic understanding regarding the first-pass metabolism and intestinal efflux that modulate the pharmacokinetics of drug and suggest the formulation strategies to enhance the bioavailability of investigated drugs. 517 $aDrug Absorption Studies 606 $aManufacturing industries$2bicssc 606 $aMedicine and Nursing$2bicssc 610 $aacetaminophen-induced hepatotoxicity 610 $aamorphous solid dispersion 610 $aBCS drug classification 610 $abioavailability 610 $abiomedical drug 610 $abreast cancer resistance protein 610 $acandesartan Cilexetil 610 $acatabolism disorder 610 $achitosan 610 $acinnarizine 610 $aD-?-Tocopherol polyethylene glycol 1000 succinate (TPGS) 610 $adissolution profiles 610 $adrug-phytochemical interaction 610 $aendocytosis 610 $aenoxaparin 610 $aenzyme 610 $aextra virgin olive oil 610 $ahepatic metabolism 610 $ahydrogel 610 $ain vivo-in vitro correlation 610 $aintestinal absorption 610 $aintestinal permeability 610 $akinetics 610 $al-phenylalanine ammonia-lyase 610 $alipid-based drug delivery system 610 $alipid-polymer hybrid nanoparticles 610 $alipolysis 610 $alipolysis-permeation 610 $aliver distribution 610 $aLY335979 610 $ameloxicam 610 $ametabolism 610 $amicrosphere 610 $amixed inhibition 610 $anaftidrofuryl oxalate 610 $ananocrystals 610 $anasal administration 610 $anon-sink condition 610 $aoral 610 $aoral mucositis 610 $aP-glycoprotein 610 $apermeability 610 $aPermeaPad 610 $apH-modulation 610 $apharmaceutical availability 610 $aphenolic compounds 610 $aphenylketonuria 610 $apoorly soluble drugs 610 $aPVPK30 610 $aquercetin 610 $arebamipide 610 $arepaglinide 610 $asecoiridoids 610 $asilymarin 610 $asolubility 610 $asolubility-permeability interplay 610 $asolubilizer additive 610 $aspray drying 610 $aspray-drying 610 $aunstirred water layer 610 $aWK-X-34 615 7$aManufacturing industries 615 7$aMedicine and Nursing 700 $aSong$b Im-Sook$4edt$01302990 702 $aSong$b Im-Sook$4oth 906 $aBOOK 912 $a9910557689203321 996 $aDrug Absorption Studies: In Situ, In Vitro and In Silico Models$93026813 997 $aUNINA LEADER 03531nam 22006135 450 001 9910483310403321 005 20251113183122.0 010 $a981-15-3438-1 024 7 $a10.1007/978-981-15-3438-6 035 $a(CKB)4100000011508872 035 $a(MiAaPQ)EBC6381024 035 $a(DE-He213)978-981-15-3438-6 035 $a(PPN)258088206 035 $a(EXLCZ)994100000011508872 100 $a20201016d2021 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aSymplectic Pseudospectral Methods for Optimal Control $eTheory and Applications in Path Planning /$fby Xinwei Wang, Jie Liu, Haijun Peng 205 $a1st ed. 2021. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2021. 215 $a1 online resource (XI, 178 p. 109 illus., 98 illus. in color.) 225 1 $aIntelligent Systems, Control and Automation: Science and Engineering,$x2213-8994 ;$v97 311 08$a981-15-3437-3 327 $aBackground -- Numerical methods for computational optimal control -- Mathematical foundations -- SPM for general nonlinear unconstrained optimal control problems -- SPM for nonlinear optimal control problems with inequality constraints -- SPM for nonlinear state-delayed optimal control problems -- From open-loop to closed-loop: Model predictive control -- Optimal maneuver of spacecraft -- Optimal path planning of UGS -- Overhead crane -- Carrier aircraft (traction system) -- Optimal vaccination strategy for a seasonally varying epidemic model. 330 $aThe book focuses on symplectic pseudospectral methods for nonlinear optimal control problems and their applications. Both the fundamental principles and engineering practice are addressed. Symplectic pseudospectral methods for nonlinear optimal control problems with complicated factors (i.e., inequality constraints, state-delay, unspecific terminal time, etc.) are solved under the framework of indirect methods. The methods developed here offer a high degree of computational efficiency and accuracy when compared with popular direct pseudospectral methods. The methods are applied to solve optimal control problems arising in various engineering fields, particularly in path planning problems for autonomous vehicles. Given its scope, the book will benefit researchers, engineers and graduate students in the fields of automatic control, path planning, ordinary differential equations, etc. . 410 0$aIntelligent Systems, Control and Automation: Science and Engineering,$x2213-8994 ;$v97 606 $aAutomatic control 606 $aMathematical optimization 606 $aCalculus of variations 606 $aAutomotive engineering 606 $aControl and Systems Theory 606 $aCalculus of Variations and Optimization 606 $aAutomotive Engineering 615 0$aAutomatic control. 615 0$aMathematical optimization. 615 0$aCalculus of variations. 615 0$aAutomotive engineering. 615 14$aControl and Systems Theory. 615 24$aCalculus of Variations and Optimization. 615 24$aAutomotive Engineering. 676 $a629.836 700 $aWang$b Xinwei$0933629 702 $aLiu$b Jie 702 $aPeng$b Haijun 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910483310403321 996 $aSymplectic pseudospectral methods for optimal control$92854000 997 $aUNINA