LEADER 03955nam 2201093z- 450 001 9910557689203321 005 20231214133312.0 035 $a(CKB)5400000000044639 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/77071 035 $a(EXLCZ)995400000000044639 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aDrug Absorption Studies: In Situ, In Vitro and In Silico Models 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 electronic resource (171 p.) 311 $a3-0365-2461-4 311 $a3-0365-2460-6 330 $aThis Book serves to highlight the mechanisms related to the low intestinal drug absorption, the strategies to overcome the obstacles or intestinal drug absorption, and in situ, in vitro, and in silico methodologies to predict to intestinal drug absorption. This Book presents a series of drug absorption studies and related technologies that predict intestinal permeation of drugs that govern the pharmacokinetic features of therapeutic drugs. It also contains the mechanistic understanding regarding the first-pass metabolism and intestinal efflux that modulate the pharmacokinetics of drug and suggest the formulation strategies to enhance the bioavailability of investigated drugs. 517 $aDrug Absorption Studies 606 $aMedicine$2bicssc 606 $aPharmaceutical industries$2bicssc 610 $arebamipide 610 $ananocrystals 610 $aoral mucositis 610 $ahydrogel 610 $aendocytosis 610 $aenoxaparin 610 $alipid?polymer hybrid nanoparticles 610 $aoral 610 $aintestinal absorption 610 $anaftidrofuryl oxalate 610 $asolubility 610 $apermeability 610 $adissolution profiles 610 $apharmaceutical availability 610 $aBCS drug classification 610 $anon-sink condition 610 $asolubility?permeability interplay 610 $aunstirred water layer 610 $apoorly soluble drugs 610 $asolubilizer additive 610 $aphenylketonuria 610 $al-phenylalanine ammonia-lyase 610 $aenzyme 610 $akinetics 610 $acatabolism disorder 610 $abiomedical drug 610 $aP-glycoprotein 610 $abreast cancer resistance protein 610 $aLY335979 610 $aWK-X-34 610 $ain vivo?in vitro correlation 610 $alipolysis-permeation 610 $alipid-based drug delivery system 610 $aPermeaPad 610 $acinnarizine 610 $alipolysis 610 $aamorphous solid dispersion 610 $acandesartan Cilexetil 610 $aPVPK30 610 $apH-modulation 610 $aspray drying 610 $abioavailability 610 $anasal administration 610 $aspray-drying 610 $achitosan 610 $amicrosphere 610 $ameloxicam 610 $asilymarin 610 $aD-?-Tocopherol polyethylene glycol 1000 succinate (TPGS) 610 $aliver distribution 610 $aacetaminophen-induced hepatotoxicity 610 $aextra virgin olive oil 610 $asecoiridoids 610 $ametabolism 610 $aphenolic compounds 610 $aintestinal permeability 610 $adrug-phytochemical interaction 610 $ahepatic metabolism 610 $amixed inhibition 610 $aquercetin 610 $arepaglinide 615 7$aMedicine 615 7$aPharmaceutical industries 700 $aSong$b Im-Sook$4edt$01302990 702 $aSong$b Im-Sook$4oth 906 $aBOOK 912 $a9910557689203321 996 $aDrug Absorption Studies: In Situ, In Vitro and In Silico Models$93026813 997 $aUNINA