Intrinsically Disordered Proteins and Chronic Diseases

• Autore: Kulkarni Prakash
• Pubblicazione: Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021
• Descrizione fisica: 1 online resource (224 p.)
• Soggetto topico: Research & information: general
• Soggetto non controllato: binding mechanism; coactivators; conformational ensemble; conformational plasticity; COR15A; depletion interaction; diffusion; disease-related proteins; drug design; dynamic configuration; electrostatics; entropic force; extremely fuzzy complex; free energy landscape; functional segments; fuzzy interactions; gene regulation; glucocorticoid receptor; IDP; intrinsic disordered protein; intrinsically disordered; intrinsically disordered protein; intrinsically disordered proteins; intrinsically disordered regions; Kinase-inducible domain interacting domain; kinetics; Late embryogenesis abundant; liquid-liquid phase separation; low-complexity sequences; membraneless organelles; microtubule associated protein; microtubules; molecular dynamics; molecular modelling; mouse double minute 2; mouse double minute 4; n/a; nuclear magnetic resonance; Nuclear magnetic resonance; optical tweezer; order-disorder transition; PAGE4; phosphomimetics; phosphorylation; protein complementation assays; protein diffusion; protein interaction; protein structure prediction; protein-protein interaction; replica exchange molecular dynamics; split-GFP reassembly; subcellular location; tau; tau-microtubule association; transactivation activity; transient secondary structure; Trifluoroethanol; tumor protein p53
• Persona (resp. second.): UverskyVladimir N; KulkarniPrakash
• Sommario/riassunto: This book is an embodiment of a series of articles that were published as part of a Special Issue of Biomolecules. It is dedicated to exploring the role of intrinsically disordered proteins (IDPs) in various chronic diseases. The main goal of the articles is to describe recent progress in elucidating the mechanisms by which IDPs cause various human diseases, such as cancer, cardiovascular disease, amyloidosis, neurodegenerative diseases, diabetes, and genetic diseases, to name a few. Contributed by leading investigators in the field, this compendium serves as a valuable resource for researchers, clinicians as well as postdoctoral fellows and graduate students
• Titolo autorizzato: Intrinsically Disordered Proteins and Chronic Diseases
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910557746903321
• Lo trovi qui: Univ. Federico II