04018nam 2201057z- 450 991055774690332120220111(CKB)5400000000045873(oapen)https://directory.doabooks.org/handle/20.500.12854/76537(oapen)doab76537(EXLCZ)99540000000004587320202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierIntrinsically Disordered Proteins and Chronic DiseasesBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (224 p.)3-0365-1262-4 3-0365-1263-2 This book is an embodiment of a series of articles that were published as part of a Special Issue of Biomolecules. It is dedicated to exploring the role of intrinsically disordered proteins (IDPs) in various chronic diseases. The main goal of the articles is to describe recent progress in elucidating the mechanisms by which IDPs cause various human diseases, such as cancer, cardiovascular disease, amyloidosis, neurodegenerative diseases, diabetes, and genetic diseases, to name a few. Contributed by leading investigators in the field, this compendium serves as a valuable resource for researchers, clinicians as well as postdoctoral fellows and graduate studentsResearch & information: generalbicsscbinding mechanismcoactivatorsconformational ensembleconformational plasticityCOR15Adepletion interactiondiffusiondisease-related proteinsdrug designdynamic configurationelectrostaticsentropic forceextremely fuzzy complexfree energy landscapefunctional segmentsfuzzy interactionsgene regulationglucocorticoid receptorIDPintrinsic disordered proteinintrinsically disorderedintrinsically disordered proteinintrinsically disordered proteinsintrinsically disordered regionsKinase-inducible domain interacting domainkineticsLate embryogenesis abundantliquid-liquid phase separationlow-complexity sequencesmembraneless organellesmicrotubule associated proteinmicrotubulesmolecular dynamicsmolecular modellingmouse double minute 2mouse double minute 4n/anuclear magnetic resonanceNuclear magnetic resonanceoptical tweezerorder-disorder transitionPAGE4phosphomimeticsphosphorylationprotein complementation assaysprotein diffusionprotein interactionprotein structure predictionprotein-protein interactionreplica exchange molecular dynamicssplit-GFP reassemblysubcellular locationtautau-microtubule associationtransactivation activitytransient secondary structureTrifluoroethanoltumor protein p53Research & information: generalKulkarni Prakashedt1299454Uversky Vladimir NedtKulkarni PrakashothUversky Vladimir NothBOOK9910557746903321Intrinsically Disordered Proteins and Chronic Diseases3025182UNINA