03981nam 2201033z- 450 991055774690332120231214133701.0(CKB)5400000000045873(oapen)https://directory.doabooks.org/handle/20.500.12854/76537(EXLCZ)99540000000004587320202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierIntrinsically Disordered Proteins and Chronic DiseasesBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 electronic resource (224 p.)3-0365-1262-4 3-0365-1263-2 This book is an embodiment of a series of articles that were published as part of a Special Issue of Biomolecules. It is dedicated to exploring the role of intrinsically disordered proteins (IDPs) in various chronic diseases. The main goal of the articles is to describe recent progress in elucidating the mechanisms by which IDPs cause various human diseases, such as cancer, cardiovascular disease, amyloidosis, neurodegenerative diseases, diabetes, and genetic diseases, to name a few. Contributed by leading investigators in the field, this compendium serves as a valuable resource for researchers, clinicians as well as postdoctoral fellows and graduate studentsResearch & information: generalbicsscIDPfuzzy interactionsprotein complementation assayssplit-GFP reassemblykineticsmembraneless organellesoptical tweezerliquid-liquid phase separationprotein diffusiondepletion interactionentropic forcelow-complexity sequencesintrinsically disordered proteinsPAGE4conformational plasticityorder-disorder transitionphosphorylationintrinsic disordered proteinextremely fuzzy complexprotein interactionbinding mechanismtumor protein p53mouse double minute 2mouse double minute 4Kinase-inducible domain interacting domainphosphomimeticsnuclear magnetic resonancetransient secondary structureCOR15ALate embryogenesis abundantTrifluoroethanolNuclear magnetic resonanceintrinsically disordered regionsfunctional segmentsdisease-related proteinsprotein-protein interactionsubcellular locationglucocorticoid receptorintrinsically disorderedtransactivation activitygene regulationcoactivatorsmicrotubule associated proteintauintrinsically disordered proteindynamic configurationfree energy landscapemicrotubuleselectrostaticsdiffusionprotein structure predictionmolecular modellingmolecular dynamicstau-microtubule associationconformational ensemblereplica exchange molecular dynamicsdrug designResearch & information: generalKulkarni Prakashedt1299454Uversky Vladimir NedtKulkarni PrakashothUversky Vladimir NothBOOK9910557746903321Intrinsically Disordered Proteins and Chronic Diseases3025182UNINA