Novel Strategies in the Development of New Therapies, Drug Substances and Drug Carriers

• Autore: Kutner Andrzej
• Pubblicazione: Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022
• Descrizione fisica: 1 online resource (450 p.)
• Soggetto topico: Chemistry; Research & information: general
• Soggetto non controllato: 1,2,4-triazole; 25 vitamin D 24-hydroxylase; A-ring; active substance delivery systems; active substance-controlled release; ADME; alkaloids; alpha-ketoglutarate; analogue actions at genes; anti-depressant therapy; anti-inflammatory activity; anticancer activity; anticancer drug; anticancer drugs; antidepressants; antimalarial; antimicrobial activity; antimicrobial compounds; antimicrobial peptide (AMP); antioxidant activity; antiparasitic agents; antiviral proteins; apoptosis; Au(III) complex; biomarker; biomedical hydrogels; calcilytic; calcimimetic; calcium-sensing receptor; cancer; cancer cells; cancer therapy; cancer treatment; CD-ring; cell cycle; cell invasion; cell migration; Chelidonium majus; ChIP-chip analysis; colon cancer; colorectal cancer; copper (II) complexes; CRISPR/Cas9; cyclooxygenase; CYP24A1; CYP24A1-dependent metabolism; CYP27B1; cytotoxic activity; cytotoxic study; cytotoxicity; defense-related proteins; depression; dermaseptin; distal enhancers; drug; drug design; drug design and discovery; drug discovery; dual 5-HT1A/SERT activity; electrochemistry; enantiomer; fluorine; frog skin peptides; genistein; genome editing; glucose metabolism; glycoconjugates; gold; gold electrode; greater celandine; hemolysis; high-grade serous ovarian cancer cells; histone deacetylase (HDAC); histone H3 acetylation; HT-29; human DNA topoisomerase; hydrogels for cosmetology; hydrogels for dermatology; IL-8; inflammation; JNK; latex; LHRH; lung cancer; major latex protein; MALDI; metabolite; metallodrugs; methotrexate; molecular docking; molecular modeling; multimodal activity; n/a; nanoparticles; organometallic; oxidation mechanisms; Phyllomedusa bicolor; Plasmodium falciparum (P. falciparum); PRI-2191; proliferation; prostate cancer; proteome analysis; pyridazinone; pyrido[1,2-c]pyrimidines; resveratrol; rickets; RNA polymerase II; SAR; self-assembled monolayer; side-chain; spectroscopic data; split luciferase-based biosensor; stereospecificity; synthesis; targeted therapy; tetrahydro-β-carbolines; TGF-β; therapeutic peptides; thiourea; transcription; transdermal active substance delivery systems; VEGF; vitamin D; vitamin D analogs; vitamin D biology and action; vitamin D hormone (1,25(OH)2D3); vitamin D receptor; vitamin D3; Warburg effect
• Persona (resp. second.): BrownGeoffrey; KallayEnikö; KutnerAndrzej
• Sommario/riassunto: This book is conceived to promote synergy between research and industrial activities in the design and development of new drugs and, therefore, is not limited to any specific aspect of development. It covers the entire process from the identification of a molecular target, studies of drug-protein interactions, the modeling and optimization of the functional activity, design and chemical synthesis, biological evaluation, and the development of new pharmaceutical carriers.The original articles and reviews are focused on the design and development of new anticancer treatments, new anticancer low-molecular-weight agents as potential drug substances, and the elucidation of their mechanisms of action. The book also includes studies on novel modulators of the serotonergic system used to treat central nervous system disorders, novel agents against infectious diseases, and the development of anti-plasmodial and anti-inflammatory agents. The successful identification of new compounds for development as drug substances comes from rich sources of medicinal plants and medicinal chemistry approaches.
• Titolo autorizzato: Novel Strategies in the Development of New Therapies, Drug Substances and Drug Carriers
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910585938903321
• Lo trovi qui: Univ. Federico II