06648nam 2201933z- 450 991058593890332120231214132846.0(CKB)5600000000483093(oapen)https://directory.doabooks.org/handle/20.500.12854/91173(EXLCZ)99560000000048309320202208d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierNovel Strategies in the Development of New Therapies, Drug Substances and Drug CarriersBaselMDPI - Multidisciplinary Digital Publishing Institute20221 electronic resource (450 p.)3-0365-4646-4 3-0365-4645-6 This book is conceived to promote synergy between research and industrial activities in the design and development of new drugs and, therefore, is not limited to any specific aspect of development. It covers the entire process from the identification of a molecular target, studies of drug–protein interactions, the modeling and optimization of the functional activity, design and chemical synthesis, biological evaluation, and the development of new pharmaceutical carriers.The original articles and reviews are focused on the design and development of new anticancer treatments, new anticancer low-molecular-weight agents as potential drug substances, and the elucidation of their mechanisms of action. The book also includes studies on novel modulators of the serotonergic system used to treat central nervous system disorders, novel agents against infectious diseases, and the development of anti-plasmodial and anti-inflammatory agents. The successful identification of new compounds for development as drug substances comes from rich sources of medicinal plants and medicinal chemistry approaches.Research & information: generalbicsscChemistrybicsscalpha-ketoglutaratecell cycleapoptosisJNKcell migrationcell invasionTGF-βVEGFglycoconjugatesmethotrexatecancer treatmentglucose metabolismdrug design and discoveryanticancer drugstargeted therapyWarburg effectantidepressantspyrido[1,2-c]pyrimidinesdual 5-HT1A/SERT activitydrug designanticancer activitylung cancerresveratrolPRI-2191vitamin Dactive substance delivery systemsbiomedical hydrogelsactive substance-controlled releasegenisteinhydrogels for cosmetologyhydrogels for dermatologytransdermal active substance delivery systemshistone deacetylase (HDAC)depressionbiomarkeranti-depressant therapyhuman DNA topoisomerasecancerdrugmolecular dockingsynthesisfluorinevitamin D3metaboliteA-ringCD-ringside-chainnanoparticlesmolecular modelingoxidation mechanismselectrochemistryMALDIspectroscopic datacytotoxic studyself-assembled monolayergold electrodemultimodal activitycalcium-sensing receptorenantiomercalcimimeticcalcilyticcolon cancerstereospecificityHT-29IL-8inflammationcyclooxygenase1,2,4-triazolepyridazinoneSARanti-inflammatory activityantioxidant activityADMEanticancer drugantimicrobial peptide (AMP)dermaseptinfrog skin peptidesLHRHprostate cancerPhyllomedusa bicolortherapeutic peptidescopper (II) complexesthioureacytotoxic activityproteome analysisantimicrobial activitymajor latex proteinChelidonium majusgreater celandinedefense-related proteinsalkaloidscancer cellsvitamin D receptorsplit luciferase-based biosensorCYP24A1-dependent metabolismCYP27B1ricketsgenome editingvitamin D biology and actiontranscriptionChIP-chip analysisdistal enhancershistone H3 acetylationRNA polymerase IIanalogue actions at genesvitamin D hormone (1,25(OH)2D3)latexantiviral proteinsantimicrobial compoundscytotoxicitydrug discoveryCRISPR/Cas9tetrahydro-β-carbolinesPlasmodium falciparum (P. falciparum)antimalarialantiparasitic agentshemolysisvitamin D analogs25 vitamin D 24-hydroxylaseCYP24A1proliferationhigh-grade serous ovarian cancer cellsgoldAu(III) complexcolorectal cancerorganometalliccancer therapymetallodrugsResearch & information: generalChemistryKutner Andrzejedt1313410Brown GeoffreyedtKallay EniköedtKutner AndrzejothBrown GeoffreyothKallay EniköothBOOK9910585938903321Novel Strategies in the Development of New Therapies, Drug Substances and Drug Carriers3031397UNINA