LEADER 00939nam0-22002771i-450- 001 990004957150403321 005 19990530 035 $a000495715 035 $aFED01000495715 035 $a(Aleph)000495715FED01 035 $a000495715 100 $a19990530g18449999km-y0itay50------ba 101 0 $aita 105 $ay-------001yy 200 1 $a<>Geschichten des aetolischen Landes, Boltes und Bundes$eIn drei Bnchernnach den Quellen dargestellt. Nebst einer historiographischen Abhandlung nber Polybus$fvon J. A. Brandstäter 210 $aBerlin$cG. Reimer$d1844. 215 $aVIII, 513 p.$d23 cm 700 1$aBrandstater,$bJ. A.$0395214 702 1$aPolybius$f<205/203 - ca 120 a. C.> 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990004957150403321 952 $aIV A 45$bBibl. 34461$fFLFBC 959 $aFLFBC 996 $aGeschichten des aetolischen Landes, Boltes und Bundes$9528016 997 $aUNINA LEADER 06683nam 2201957z- 450 001 9910585938903321 005 20220812 035 $a(CKB)5600000000483093 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/91173 035 $a(oapen)doab91173 035 $a(EXLCZ)995600000000483093 100 $a20202208d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aNovel Strategies in the Development of New Therapies, Drug Substances and Drug Carriers 210 $aBasel$cMDPI - Multidisciplinary Digital Publishing Institute$d2022 215 $a1 online resource (450 p.) 311 08$a3-0365-4646-4 311 08$a3-0365-4645-6 330 $aThis book is conceived to promote synergy between research and industrial activities in the design and development of new drugs and, therefore, is not limited to any specific aspect of development. It covers the entire process from the identification of a molecular target, studies of drug-protein interactions, the modeling and optimization of the functional activity, design and chemical synthesis, biological evaluation, and the development of new pharmaceutical carriers.The original articles and reviews are focused on the design and development of new anticancer treatments, new anticancer low-molecular-weight agents as potential drug substances, and the elucidation of their mechanisms of action. The book also includes studies on novel modulators of the serotonergic system used to treat central nervous system disorders, novel agents against infectious diseases, and the development of anti-plasmodial and anti-inflammatory agents. The successful identification of new compounds for development as drug substances comes from rich sources of medicinal plants and medicinal chemistry approaches. 606 $aChemistry$2bicssc 606 $aResearch & information: general$2bicssc 610 $a1,2,4-triazole 610 $a25 vitamin D 24-hydroxylase 610 $aA-ring 610 $aactive substance delivery systems 610 $aactive substance-controlled release 610 $aADME 610 $aalkaloids 610 $aalpha-ketoglutarate 610 $aanalogue actions at genes 610 $aanti-depressant therapy 610 $aanti-inflammatory activity 610 $aanticancer activity 610 $aanticancer drug 610 $aanticancer drugs 610 $aantidepressants 610 $aantimalarial 610 $aantimicrobial activity 610 $aantimicrobial compounds 610 $aantimicrobial peptide (AMP) 610 $aantioxidant activity 610 $aantiparasitic agents 610 $aantiviral proteins 610 $aapoptosis 610 $aAu(III) complex 610 $abiomarker 610 $abiomedical hydrogels 610 $acalcilytic 610 $acalcimimetic 610 $acalcium-sensing receptor 610 $acancer 610 $acancer cells 610 $acancer therapy 610 $acancer treatment 610 $aCD-ring 610 $acell cycle 610 $acell invasion 610 $acell migration 610 $aChelidonium majus 610 $aChIP-chip analysis 610 $acolon cancer 610 $acolorectal cancer 610 $acopper (II) complexes 610 $aCRISPR/Cas9 610 $acyclooxygenase 610 $aCYP24A1 610 $aCYP24A1-dependent metabolism 610 $aCYP27B1 610 $acytotoxic activity 610 $acytotoxic study 610 $acytotoxicity 610 $adefense-related proteins 610 $adepression 610 $adermaseptin 610 $adistal enhancers 610 $adrug 610 $adrug design 610 $adrug design and discovery 610 $adrug discovery 610 $adual 5-HT1A/SERT activity 610 $aelectrochemistry 610 $aenantiomer 610 $afluorine 610 $afrog skin peptides 610 $agenistein 610 $agenome editing 610 $aglucose metabolism 610 $aglycoconjugates 610 $agold 610 $agold electrode 610 $agreater celandine 610 $ahemolysis 610 $ahigh-grade serous ovarian cancer cells 610 $ahistone deacetylase (HDAC) 610 $ahistone H3 acetylation 610 $aHT-29 610 $ahuman DNA topoisomerase 610 $ahydrogels for cosmetology 610 $ahydrogels for dermatology 610 $aIL-8 610 $ainflammation 610 $aJNK 610 $alatex 610 $aLHRH 610 $alung cancer 610 $amajor latex protein 610 $aMALDI 610 $ametabolite 610 $ametallodrugs 610 $amethotrexate 610 $amolecular docking 610 $amolecular modeling 610 $amultimodal activity 610 $an/a 610 $ananoparticles 610 $aorganometallic 610 $aoxidation mechanisms 610 $aPhyllomedusa bicolor 610 $aPlasmodium falciparum (P. falciparum) 610 $aPRI-2191 610 $aproliferation 610 $aprostate cancer 610 $aproteome analysis 610 $apyridazinone 610 $apyrido[1,2-c]pyrimidines 610 $aresveratrol 610 $arickets 610 $aRNA polymerase II 610 $aSAR 610 $aself-assembled monolayer 610 $aside-chain 610 $aspectroscopic data 610 $asplit luciferase-based biosensor 610 $astereospecificity 610 $asynthesis 610 $atargeted therapy 610 $atetrahydro-?-carbolines 610 $aTGF-? 610 $atherapeutic peptides 610 $athiourea 610 $atranscription 610 $atransdermal active substance delivery systems 610 $aVEGF 610 $avitamin D 610 $avitamin D analogs 610 $avitamin D biology and action 610 $avitamin D hormone (1,25(OH)2D3) 610 $avitamin D receptor 610 $avitamin D3 610 $aWarburg effect 615 7$aChemistry 615 7$aResearch & information: general 700 $aKutner$b Andrzej$4edt$01313410 702 $aBrown$b Geoffrey$4edt 702 $aKallay$b Eniko?$4edt 702 $aKutner$b Andrzej$4oth 702 $aBrown$b Geoffrey$4oth 702 $aKallay$b Eniko?$4oth 906 $aBOOK 912 $a9910585938903321 996 $aNovel Strategies in the Development of New Therapies, Drug Substances and Drug Carriers$93031397 997 $aUNINA