LEADER 01155dam0 2200349 450 001 990000821230203316 005 20170607120705.0 035 $a0082123 035 $aUSA010082123 035 $a(ALEPH)000082123USA01 035 $a0082123 100 $a19950410d1963----||ita|01 ba 101 $aita 102 $aIT 105 $a|||| ||||| 200 1 $aArchivio storico siciliano$eindice generale dell'Archivio storico siciliano$epubblicazione periodica della Societa siciliana per la storia patria$e1873-1956 210 $aPalermo$cSoc. siciliana per la storia patria$d1963. 215 $a129 p.$d25 cm 300 $aIn testa al front.: Societa siciliana per la storia patria 610 0 $aArchivio storico siciliano$aIndici$a1873-1956 676 $a945.8 801 0$aIT$bsalbc$gISBD 912 $a990000821230203316 959 $aSE 969 $aUMA 979 $aPATTY$b90$c20011220$lUSA01$h1738 979 $aPATTY$b90$c20011220$lUSA01$h1739 979 $aPATTY$b90$c20011220$lUSA01$h1741 979 $c20020403$lUSA01$h1728 979 $aPATRY$b90$c20040406$lUSA01$h1657 996 $aARCHIVIO storico Siciliano$9523083 997 $aUNISA LEADER 01103nam0-22003131i-450- 001 990002052390403321 005 20090608162030.0 035 $a000205239 035 $aFED01000205239 035 $a(Aleph)000205239FED01 035 $a000205239 100 $a20090608d1969----km-y0itay50------ba 101 0 $aeng 200 1 $aSymposium on potentials in crop protection$eNew York State agricultural experiment Station, Geneva, Cornell University, December 1969$eproceedings 210 $aGeneva$cNew York State agricultural experiment Station, Cornell University$d[1969] 215 $a54 p.$cill.$d28 cm 610 0 $aAntiparassitari 676 $a632.9 710 12$aSymposium on potentials in crop protection$f<1969 ;$eGeneva>$087511 712 02$aNew York State Agricultural Experiment Station 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990002052390403321 952 $a61 VII B.2/141$b6936 (20/4/98)$fDAGEN 952 $a60 632.9 A 1$b41944$fFAGBC 959 $aDAGEN 959 $aFAGBC 996 $aSymposium on potentials in crop protection$9406104 997 $aUNINA LEADER 06683nam 2201957z- 450 001 9910585938903321 005 20220812 035 $a(CKB)5600000000483093 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/91173 035 $a(oapen)doab91173 035 $a(EXLCZ)995600000000483093 100 $a20202208d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aNovel Strategies in the Development of New Therapies, Drug Substances and Drug Carriers 210 $aBasel$cMDPI - Multidisciplinary Digital Publishing Institute$d2022 215 $a1 online resource (450 p.) 311 08$a3-0365-4646-4 311 08$a3-0365-4645-6 330 $aThis book is conceived to promote synergy between research and industrial activities in the design and development of new drugs and, therefore, is not limited to any specific aspect of development. It covers the entire process from the identification of a molecular target, studies of drug-protein interactions, the modeling and optimization of the functional activity, design and chemical synthesis, biological evaluation, and the development of new pharmaceutical carriers.The original articles and reviews are focused on the design and development of new anticancer treatments, new anticancer low-molecular-weight agents as potential drug substances, and the elucidation of their mechanisms of action. The book also includes studies on novel modulators of the serotonergic system used to treat central nervous system disorders, novel agents against infectious diseases, and the development of anti-plasmodial and anti-inflammatory agents. The successful identification of new compounds for development as drug substances comes from rich sources of medicinal plants and medicinal chemistry approaches. 606 $aChemistry$2bicssc 606 $aResearch & information: general$2bicssc 610 $a1,2,4-triazole 610 $a25 vitamin D 24-hydroxylase 610 $aA-ring 610 $aactive substance delivery systems 610 $aactive substance-controlled release 610 $aADME 610 $aalkaloids 610 $aalpha-ketoglutarate 610 $aanalogue actions at genes 610 $aanti-depressant therapy 610 $aanti-inflammatory activity 610 $aanticancer activity 610 $aanticancer drug 610 $aanticancer drugs 610 $aantidepressants 610 $aantimalarial 610 $aantimicrobial activity 610 $aantimicrobial compounds 610 $aantimicrobial peptide (AMP) 610 $aantioxidant activity 610 $aantiparasitic agents 610 $aantiviral proteins 610 $aapoptosis 610 $aAu(III) complex 610 $abiomarker 610 $abiomedical hydrogels 610 $acalcilytic 610 $acalcimimetic 610 $acalcium-sensing receptor 610 $acancer 610 $acancer cells 610 $acancer therapy 610 $acancer treatment 610 $aCD-ring 610 $acell cycle 610 $acell invasion 610 $acell migration 610 $aChelidonium majus 610 $aChIP-chip analysis 610 $acolon cancer 610 $acolorectal cancer 610 $acopper (II) complexes 610 $aCRISPR/Cas9 610 $acyclooxygenase 610 $aCYP24A1 610 $aCYP24A1-dependent metabolism 610 $aCYP27B1 610 $acytotoxic activity 610 $acytotoxic study 610 $acytotoxicity 610 $adefense-related proteins 610 $adepression 610 $adermaseptin 610 $adistal enhancers 610 $adrug 610 $adrug design 610 $adrug design and discovery 610 $adrug discovery 610 $adual 5-HT1A/SERT activity 610 $aelectrochemistry 610 $aenantiomer 610 $afluorine 610 $afrog skin peptides 610 $agenistein 610 $agenome editing 610 $aglucose metabolism 610 $aglycoconjugates 610 $agold 610 $agold electrode 610 $agreater celandine 610 $ahemolysis 610 $ahigh-grade serous ovarian cancer cells 610 $ahistone deacetylase (HDAC) 610 $ahistone H3 acetylation 610 $aHT-29 610 $ahuman DNA topoisomerase 610 $ahydrogels for cosmetology 610 $ahydrogels for dermatology 610 $aIL-8 610 $ainflammation 610 $aJNK 610 $alatex 610 $aLHRH 610 $alung cancer 610 $amajor latex protein 610 $aMALDI 610 $ametabolite 610 $ametallodrugs 610 $amethotrexate 610 $amolecular docking 610 $amolecular modeling 610 $amultimodal activity 610 $an/a 610 $ananoparticles 610 $aorganometallic 610 $aoxidation mechanisms 610 $aPhyllomedusa bicolor 610 $aPlasmodium falciparum (P. falciparum) 610 $aPRI-2191 610 $aproliferation 610 $aprostate cancer 610 $aproteome analysis 610 $apyridazinone 610 $apyrido[1,2-c]pyrimidines 610 $aresveratrol 610 $arickets 610 $aRNA polymerase II 610 $aSAR 610 $aself-assembled monolayer 610 $aside-chain 610 $aspectroscopic data 610 $asplit luciferase-based biosensor 610 $astereospecificity 610 $asynthesis 610 $atargeted therapy 610 $atetrahydro-?-carbolines 610 $aTGF-? 610 $atherapeutic peptides 610 $athiourea 610 $atranscription 610 $atransdermal active substance delivery systems 610 $aVEGF 610 $avitamin D 610 $avitamin D analogs 610 $avitamin D biology and action 610 $avitamin D hormone (1,25(OH)2D3) 610 $avitamin D receptor 610 $avitamin D3 610 $aWarburg effect 615 7$aChemistry 615 7$aResearch & information: general 700 $aKutner$b Andrzej$4edt$01313410 702 $aBrown$b Geoffrey$4edt 702 $aKallay$b Eniko?$4edt 702 $aKutner$b Andrzej$4oth 702 $aBrown$b Geoffrey$4oth 702 $aKallay$b Eniko?$4oth 906 $aBOOK 912 $a9910585938903321 996 $aNovel Strategies in the Development of New Therapies, Drug Substances and Drug Carriers$93031397 997 $aUNINA