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Structural and functional characterization of the immunoproteasome / / Eva Maria Huber



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Autore: Huber Eva Maria Visualizza persona
Titolo: Structural and functional characterization of the immunoproteasome / / Eva Maria Huber Visualizza cluster
Pubblicazione: Cham [Switzerland] : , : Springer, , 2013
Edizione: 1st ed. 2013.
Descrizione fisica: 1 online resource (xix, 82 pages) : illustrations (some color)
Disciplina: 572.636
Soggetto topico: Molecular immunology
Analytical biochemistry
Note generali: "ISSN: 2190-5053."
Nota di bibliografia: Includes bibliographical references.
Nota di contenuto: Introduction -- Objective -- Materials and Methods -- Results -- Discussion -- Appendix.
Sommario/riassunto: In this acclaimed thesis, Eva Maria Huber reveals ground-breaking results by elucidating the crystal structure of the murine immunoproteasome in complex with a selective inhibitor. Huber does this by performing multidisciplinary methodologies including X-ray crystallography, fluorescence spectroscopy and mutagenesis experiments. Her exceptional results explore the immunoproteasome complex structures and are of outstanding importance for future scientific research especially in the pharmaceutical industry. These results will enable the functional analysis of individual proteasome subunits and support the development of novel drugs for autoimmune diseases such as multiple sclerosis or rheumatoid arthritis.
Titolo autorizzato: Structural and Functional Characterization of the Immunoproteasome  Visualizza cluster
ISBN: 3-319-01556-7
Formato: Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione: Inglese
Record Nr.: 9910437806303321
Lo trovi qui: Univ. Federico II
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Serie: Springer theses.