02245oam 2200457 450 991043780630332120190911112725.03-319-01556-710.1007/978-3-319-01556-9(OCoLC)859597454(MiFhGG)GVRL6WKT(EXLCZ)99371000000001910220130710d2013 uy 0engurun|---uuuuatxtccrStructural and functional characterization of the immunoproteasome /Eva Maria Huber1st ed. 2013.Cham [Switzerland] :Springer,2013.1 online resource (xix, 82 pages) illustrations (some color)Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053"ISSN: 2190-5053."3-319-01555-9 Includes bibliographical references.Introduction -- Objective -- Materials and Methods -- Results -- Discussion -- Appendix.In this acclaimed thesis, Eva Maria Huber reveals ground-breaking results by elucidating the crystal structure of the murine immunoproteasome in complex with a selective inhibitor. Huber does this by performing multidisciplinary methodologies including X-ray crystallography, fluorescence spectroscopy and mutagenesis experiments. Her exceptional results explore the immunoproteasome complex structures and are of outstanding importance for future scientific research especially in the pharmaceutical industry. These results will enable the functional analysis of individual proteasome subunits and support the development of novel drugs for autoimmune diseases such as multiple sclerosis or rheumatoid arthritis.Springer theses.Molecular immunologyAnalytical biochemistryMolecular immunology.Analytical biochemistry.572.636Huber Eva Mariaauthttp://id.loc.gov/vocabulary/relators/aut1062212MiFhGGMiFhGGBOOK9910437806303321Structural and Functional Characterization of the Immunoproteasome2523532UNINA