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010   $a3-319-01556-7
024 7 $a10.1007/978-3-319-01556-9
035   $a(OCoLC)859597454
035   $a(MiFhGG)GVRL6WKT
035   $a(EXLCZ)993710000000019102
100   $a20130710d2013      uy             0
101 0 $aeng
135   $aurun|---uuuua
181   $ctxt
182   $cc
183   $acr
200 10$aStructural and functional characterization of the immunoproteasome /$fEva Maria Huber
205   $a1st ed. 2013.
210  1$aCham [Switzerland] :$cSpringer,$d2013.
215   $a1 online resource (xix, 82 pages) $cillustrations (some color)
225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053
300   $a"ISSN: 2190-5053."
311   $a3-319-01555-9 
320   $aIncludes bibliographical references.
327   $aIntroduction -- Objective -- Materials and Methods -- Results -- Discussion -- Appendix.
330   $aIn this acclaimed thesis, Eva Maria Huber reveals ground-breaking results by elucidating the crystal structure of the murine immunoproteasome in complex with a selective inhibitor. Huber does this by performing multidisciplinary methodologies including X-ray crystallography, fluorescence spectroscopy and mutagenesis experiments. Her exceptional results explore the immunoproteasome complex structures and are of outstanding importance for future scientific research especially in the pharmaceutical industry. These results will enable the functional analysis of individual proteasome subunits and support the development of novel drugs for autoimmune diseases such as multiple sclerosis or rheumatoid arthritis.
410  0$aSpringer theses.
606   $aMolecular immunology
606   $aAnalytical biochemistry
615  0$aMolecular immunology.
615  0$aAnalytical biochemistry.
676   $a572.636
700   $aHuber$b Eva Maria$4aut$4http://id.loc.gov/vocabulary/relators/aut$01062212
801  0$bMiFhGG
801  1$bMiFhGG
906   $aBOOK
912   $a9910437806303321
996   $aStructural and Functional Characterization of the Immunoproteasome$92523532
997   $aUNINA