G Protein-Coupled Receptor Kinases (GRKs) and Beta-Arrestins: New Insights into Disease Regulators

• Autore: Hattori Yuichi
• Pubblicazione: Frontiers Media SA, 2020
• Descrizione fisica: 1 online resource (182 p.)
• Soggetto topico: Pharmacology; Science: general issues
• Soggetto non controllato: beta-arrestins; cancer; cardiovascular; GRK; inflammation
• Persona (resp. second.): MichelMartin C; HattoriYuichi
• Sommario/riassunto: G protein-coupled receptor kinases (GRKs) and arrestins were initially identified as a pivotal player in the process of desensitization of agonist-activated G protein-coupled receptors (GPCRs). However, growing evidence suggests GRKs and arrestins fulfill a vital role in regulating a variety of cellular proteins involved in signal transduction independently of GPCRs. Thus, GRKs and arrestins can interact with non-GPCRs. GRKs and arrestins may directly affect functioning of non-GPCRs or indirectly regulate non-GPCR signaling. In addition, emerging evidence supports that changes in function and/or expression of GRKs and arrestins may be important in cardiovascular, inflammatory, metabolic, or cancer pathologies. A better understanding of the pathological roles of GRKs and arrestins would provide a basis for new therapeutic targets in different human diseases.
• Altri titoli varianti: G Protein-Coupled Receptor Kinases
• Titolo autorizzato: G Protein-Coupled Receptor Kinases (GRKs) and Beta-Arrestins: New Insights into Disease Regulators
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910557222003321
• Lo trovi qui: Univ. Federico II