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035   $a(CKB)5400000000041724
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/73699
035   $a(EXLCZ)995400000000041724
100   $a20202111d2020      |y             0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aG Protein-Coupled Receptor Kinases (GRKs) and Beta-Arrestins: New Insights into Disease Regulators
210   $cFrontiers Media SA$d2020
215   $a1 electronic resource (182 p.)
311   $a2-88963-547-3 
330   $aG protein-coupled receptor kinases (GRKs) and arrestins were initially identified as a pivotal player in the process of desensitization of agonist-activated G protein-coupled receptors (GPCRs). However, growing evidence suggests GRKs and arrestins fulfill a vital role in regulating a variety of cellular proteins involved in signal transduction independently of GPCRs. Thus, GRKs and arrestins can interact with non-GPCRs. GRKs and arrestins may directly affect functioning of non-GPCRs or indirectly regulate non-GPCR signaling. In addition, emerging evidence supports that changes in function and/or expression of GRKs and arrestins may be important in cardiovascular, inflammatory, metabolic, or cancer pathologies. A better understanding of the pathological roles of GRKs and arrestins would provide a basis for new therapeutic targets in different human diseases.
517   $aG Protein-Coupled Receptor Kinases 
606   $aScience: general issues$2bicssc
606   $aPharmacology$2bicssc
610   $aGRK
610   $abeta-arrestins
610   $acardiovascular
610   $ainflammation
610   $acancer
615  7$aScience: general issues
615  7$aPharmacology
700   $aHattori$b Yuichi$4edt$01302137
702   $aMichel$b Martin C$4edt
702   $aHattori$b Yuichi$4oth
702   $aMichel$b Martin C$4oth
906   $aBOOK
912   $a9910557222003321
996   $aG Protein-Coupled Receptor Kinases (GRKs) and Beta-Arrestins: New Insights into Disease Regulators$93026157
997   $aUNINA