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1. |
Record Nr. |
UNIORUON00341777 |
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Autore |
CALLOW, Philip |
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Titolo |
Son and lover : the young Lawrence / Philip Callow |
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Pubbl/distr/stampa |
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London, : Bodley Head, 1975 |
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ISBN |
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Descrizione fisica |
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316 p., 24 c. di tav. : ill. ; 22 cm. |
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Disciplina |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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2. |
Record Nr. |
UNINA9910557222003321 |
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Autore |
Hattori Yuichi |
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Titolo |
G Protein-Coupled Receptor Kinases (GRKs) and Beta-Arrestins: New Insights into Disease Regulators |
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Pubbl/distr/stampa |
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Descrizione fisica |
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1 online resource (182 p.) |
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Soggetti |
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Pharmacology |
Science: general issues |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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G protein-coupled receptor kinases (GRKs) and arrestins were initially identified as a pivotal player in the process of desensitization of agonist-activated G protein-coupled receptors (GPCRs). However, |
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growing evidence suggests GRKs and arrestins fulfill a vital role in regulating a variety of cellular proteins involved in signal transduction independently of GPCRs. Thus, GRKs and arrestins can interact with non-GPCRs. GRKs and arrestins may directly affect functioning of non-GPCRs or indirectly regulate non-GPCR signaling. In addition, emerging evidence supports that changes in function and/or expression of GRKs and arrestins may be important in cardiovascular, inflammatory, metabolic, or cancer pathologies. A better understanding of the pathological roles of GRKs and arrestins would provide a basis for new therapeutic targets in different human diseases. |
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