Advances in Mechanisms of Renal Fibrosis

• Autore: David J. Nikolic-Paterson
• Pubblicazione: Frontiers Media SA, 2018
• Descrizione fisica: 1 online resource (84 p.)
• Soggetto topico: Physiology
• Soggetto non controllato: BMP7; fibroblast; HDAC; HIPK2; JNK; miRNA; non-classical RAS; Smad; TGF-beta
• Persona (resp. second.): Hui Y. Lan
• Sommario/riassunto: Scarring of the glomerular and tubulointerstitial compartments is a hallmark of progressive kidney disease. Renal fibrosis involves a complex interplay between kidney cells, leukocytes and fibroblasts in which transforming growth factor-β (TGF-β) plays a key role. This eBook provides a comprehensive update on TGF-β signalling pathways and introduces a range of cellular and molecular mechanisms involved in renal fibrosis both upstream and downstream of TGF-β. The wide variety of potential new targets described herein bodes well for the future development of effective therapies to tackle the major clinical problem of progressive renal fibrosis.
• Titolo autorizzato: Advances in Mechanisms of Renal Fibrosis
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910346754103321
• Lo trovi qui: Univ. Federico II