01849nam 2200445z- 450 991034675410332120210211(CKB)4920000000094173(oapen)https://directory.doabooks.org/handle/20.500.12854/40307(oapen)doab40307(EXLCZ)99492000000009417320202102d2018 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierAdvances in Mechanisms of Renal FibrosisFrontiers Media SA20181 online resource (84 p.)Frontiers Research Topics2-88945-499-1 Scarring of the glomerular and tubulointerstitial compartments is a hallmark of progressive kidney disease. Renal fibrosis involves a complex interplay between kidney cells, leukocytes and fibroblasts in which transforming growth factor-β (TGF-β) plays a key role. This eBook provides a comprehensive update on TGF-β signalling pathways and introduces a range of cellular and molecular mechanisms involved in renal fibrosis both upstream and downstream of TGF-β. The wide variety of potential new targets described herein bodes well for the future development of effective therapies to tackle the major clinical problem of progressive renal fibrosis.PhysiologybicsscBMP7fibroblastHDACHIPK2JNKmiRNAnon-classical RASSmadTGF-betaPhysiologyDavid J. Nikolic-Patersonauth1317906Hui Y. LanauthBOOK9910346754103321Advances in Mechanisms of Renal Fibrosis3033077UNINA