LEADER 01770nam  2200409z- 450 
001 9910346754103321
005 20231214133718.0
035   $a(CKB)4920000000094173
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/40307
035   $a(EXLCZ)994920000000094173
100   $a20202102d2018      |y             0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aAdvances in Mechanisms of Renal Fibrosis
210   $cFrontiers Media SA$d2018
215   $a1 electronic resource (84 p.)
225 1 $aFrontiers Research Topics
311   $a2-88945-499-1 
330   $aScarring of the glomerular and tubulointerstitial compartments is a hallmark of progressive kidney disease. Renal fibrosis involves a complex interplay between kidney cells, leukocytes and fibroblasts in which transforming growth factor-? (TGF-?) plays a key role. This eBook provides a comprehensive update on TGF-? signalling pathways and introduces a range of cellular and molecular mechanisms involved in renal fibrosis both upstream and downstream of TGF-?. The wide variety of potential new targets described herein bodes well for the future development of effective therapies to tackle the major clinical problem of progressive renal fibrosis.
610   $aTGF-beta
610   $afibroblast
610   $aJNK
610   $amiRNA
610   $aSmad
610   $anon-classical RAS
610   $aBMP7
610   $aHDAC
610   $aHIPK2
700   $aDavid J. Nikolic-Paterson$4auth$01317906
702   $aHui Y. Lan$4auth
906   $aBOOK
912   $a9910346754103321
996   $aAdvances in Mechanisms of Renal Fibrosis$93033077
997   $aUNINA