Novel Anti-cancer Agents and Cellular Targets and Their Mechanism(s) of Action

• Autore: Allison Simon J
• Pubblicazione: MDPI - Multidisciplinary Digital Publishing Institute, 2022
• Descrizione fisica: 1 online resource (206 p.)
• Soggetto topico: History of engineering & technology; Technology: general issues
• Soggetto non controllato: 5-FU resistance; 8-hydroxydaidzein; affibody drug conjugate (AffiDC); affibody molecule; albumin binding domain; angiogenesis; anti-cancer agent; anticancer drug; apoptosis; AQ4N; autophagy; B-lactam steroid alkylators; BCR-ABL; biomarker; bioprecursor; breast cancer; BxPC-3; c-myc; cancer hallmarks; CCN1; colorectal cancer; Connectivity Map; CYP1A1; CYP1B1; CYP2W1; Cytochrome P450; DM1; drug repurposing; duocarmycin; EGFR tyrosine kinase inhibitor; emtansine; expression; gene silencing; Genomics of Drug Sensitivity in Cancer; glioblastoma; HepG2; Huh7; human epidermal growth factor receptor 3 (HER3); hybrid steroidal alkylating agents; in vivo imaging; invasion; isatin sulfonamides; K562; MAPK; mesenchymal-amoeboid transition; microtubule acetylation; migration; molecular docking; n/a; nanoparticles; nanosystems; NF-κB; oncogene; ovarian cancer; phortress; photon upconversion; PLGA; poly (ADP-ribose) polymerase inhibitors; prodrug; RNA interference; siRNA; synthetic lethality; triple-negative breast cancer; triplet-triplet annihilation
• Persona (resp. second.): AllisonSimon J
• Sommario/riassunto: Patient outcomes remain poor for many cancers despite improvements in treatments and new molecular-targeted biomedicines for certain cancer types or subtypes. Dose-limiting toxicity, a narrow therapeutic index, and the development of resistance to traditional anti-cancer agents are well-established. It is apparent that inherent and acquired drug resistance are major challenges with molecular-targeted agents and that on- as well as off-target side effects can still occur. Other issues include drug metabolism by the body and safely supplying a sufficient amount of active drug to the tumor cells. There is a clear and urgent need for new molecular targets and drugs that specifically target cancer cells in different ways to existing approved drugs. This book, through a collection of eight research articles and two review articles from the Biomedicines themed Special Issue 'Novel Anti-Cancer Agents and Cellular Targets and Their Mechanism(s) of Action', provides a snapshot of some of the diverse and exciting research approaches being taken by the cancer research community in trying to address some of these therapeutic challenges.
• Altri titoli varianti: Novel Anti-cancer Agents and Cellular Targets and Their Mechanism
• Titolo autorizzato: Novel Anti-cancer Agents and Cellular Targets and Their Mechanism(s) of Action
• ISBN: 3-0365-5222-7
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910619465503321
• Lo trovi qui: Univ. Federico II