Metallomics : analytical techniques and speciation methods / / edited by Bernhard Michalke

• Pubblicazione: Weinhem, Germany : , : Wiley-VCH, , [2016]; 2016
• Descrizione fisica: 1 online resource (499 p.)
• Disciplina: 338.4779102854678
• Soggetto topico: Metals - Physiological effect
• Soggetto non controllato: Proteins; Science
• Persona (resp. second.): MichalkeBernhard
• Note generali: Includes index.
• Nota di contenuto: Cover; Title Page; Copyright; Contents; List of Contributors; Preface; Part I Analytical Methods and Strategies in Metallomics; Chapter 1 The Position of Metallomics Within Other Omics Fields; 1.1 Introduction; 1.2 Metallome and Metallomics in Relation to Other ""-Ome"" and ""-Omics"" Fields; 1.2.1 Genomics; 1.2.2 Transcriptomics; 1.2.3 Proteomics; 1.2.4 Metabolomics; 1.2.5 Metallomics; 1.3 Is Metallomics Feasible as a Global Study of the Metallome; 1.4 Approaching the Metallome: Study of Metallome Subgroups; 1.5 Analytical Strategies in Metallomics; 1.5.1 Element Mass Spectrometry (ICP-MS) ; 1.5.2 Coupling Techniques1.5.3 Elemental Imaging Techniques; 1.5.4 Bioinformatic Approaches; 1.6 Functional Connections Between DNA, Proteins, Metabolites, and Metals; 1.7 Metallothiolomics as Example for Metallomics Studies of a Metallome Subgroup; 1.8 Concluding Remarks; References; Chapter 2 Coupling Techniques and Orthogonal Combination of Mass Spectrometric Techniques; 2.1 Introduction; 2.2 Analytical Techniques for Metallomics; 2.2.1 Overview about Available Separation Techniques; 2.3 Ionization Principles and Mass Spectrometric Detectors for Speciation ; 2.3.1 Element-Specific Detection with ICP-Based Techniques2.3.2 Electrospray Ionization-Mass Spectrometry (ESI-MS); 2.3.3 Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Techniques (MALDI-MS); 2.4 Overview about Coupling Techniques; 2.4.1 LC Couplings; 2.4.2 Coupling of CE and ICP-MS; 2.4.3 Laser Ablation (LA); 2.4.4 Gas Chromatography (GC); 2.5 Final Remarks and Outlook; References; Chapter 3 Quality Control in Speciation Analysis Using HPLC with ICP-MS and ESI MS/MS: Focus on Quantitation Strategies Using Isotope Dilution Analysis; 3.1 Introduction ; 3.2 Synergetic Use of Elemental and Organic Mass Spectrometry in Compound Quantitation and Quality Assurance of Food Selenium Speciation3.2.1 Quality Assurance in Species Quantitation; 3.2.2 Quality Assurance in Species Identification; 3.3 The Role of Species-Specific Isotope Dilution in Increasing Metrological Traceability for the Quantification of Bioinorganic Species; 3.3.1 IDMS and Speciation Analysis; 3.3.2 Quantitative Se Speciation in Food/Supplements by Species-Specific IDMS: Production of ""Speciated"" Reference Materials ; 3.3.3 Species-Specific Double IDMS Quantification of Plasma Selenoproteins: Advantages and Limitations in Comparison with the Species-Unspecific IDMS Approach3.3.4 Application of Species-Specific Double Spike IDMS to Account for Redox Exchange between Cr(III) and Cr(VI) Species: Practical Considerations for Quality Assurance; References; Chapter 4 Novel Methods for Bioimaging Including LA-ICP-MS, NanoSIMS, TEM/X-EDS, and SXRF; 4.1 Introduction; 4.2 Bioimaging by LA-ICP-MS; 4.2.1 Principle; 4.2.2 Elemental Bioimaging by LA-ICP-MS; 4.2.3 Quantitative Bioimaging by LA-ICP-MS ; 4.2.4 Proteomic Bioimaging by LA-ICP-MS
• Sommario/riassunto: Latest developments, new insights and knowledge derived from speciation analysis in one unique compilation: The reader gets acquainted with relevant instrumental as well as application aspects of metallomics approaches, paving the road to understanding fate, pathway, and action of metals in environment and organisms. Upon an introductory chapter on analytical methods and strategies, the full bandwidth of applications is discussed. Expert chapter authors cast spotlights on recent topics such as metallomics applications to environmental and nutrition studies as well as biology and medicine. Special chapters deal with the impact of manganese and iron on neurodegeneration, and the impact of nanoparticles on health.
• Titolo autorizzato: Metallomics
• ISBN: 3-527-69493-5; 3-527-69491-9; 3-527-69490-0
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910830000203321
• Lo trovi qui: Univ. Federico II