LEADER 05156nam 2200601 450 001 9910830000203321 005 20200520144314.0 010 $a3-527-69493-5 010 $a3-527-69491-9 010 $a3-527-69490-0 024 7 $a10.1002/9783527694907 035 $a(CKB)4330000000010666 035 $a(EBL)4688953 035 $a(MiAaPQ)EBC4688953 035 $a(Au-PeEL)EBL4688953 035 $a(CaPaEBR)ebr11266621 035 $a(CaONFJC)MIL956157 035 $a(OCoLC)958465969 035 $a(NjHacI)994330000000010666 035 $a(BIP)051236942 035 $a(EXLCZ)994330000000010666 100 $a20161010h20162016 uy| 0 101 0 $aeng 135 $aur|n|---||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 00$aMetallomics $eanalytical techniques and speciation methods /$fedited by Bernhard Michalke 210 1$aWeinhem, Germany :$cWiley-VCH,$d[2016] 210 4$d2016 215 $a1 online resource (499 p.) 300 $aIncludes index. 311 $a3-527-33969-8 327 $aCover; Title Page; Copyright; Contents; List of Contributors; Preface; Part I Analytical Methods and Strategies in Metallomics; Chapter 1 The Position of Metallomics Within Other Omics Fields; 1.1 Introduction; 1.2 Metallome and Metallomics in Relation to Other ""-Ome"" and ""-Omics"" Fields; 1.2.1 Genomics; 1.2.2 Transcriptomics; 1.2.3 Proteomics; 1.2.4 Metabolomics; 1.2.5 Metallomics; 1.3 Is Metallomics Feasible as a Global Study of the Metallome; 1.4 Approaching the Metallome: Study of Metallome Subgroups; 1.5 Analytical Strategies in Metallomics; 1.5.1 Element Mass Spectrometry (ICP-MS) 327 $a1.5.2 Coupling Techniques1.5.3 Elemental Imaging Techniques; 1.5.4 Bioinformatic Approaches; 1.6 Functional Connections Between DNA, Proteins, Metabolites, and Metals; 1.7 Metallothiolomics as Example for Metallomics Studies of a Metallome Subgroup; 1.8 Concluding Remarks; References; Chapter 2 Coupling Techniques and Orthogonal Combination of Mass Spectrometric Techniques; 2.1 Introduction; 2.2 Analytical Techniques for Metallomics; 2.2.1 Overview about Available Separation Techniques; 2.3 Ionization Principles and Mass Spectrometric Detectors for Speciation 327 $a2.3.1 Element-Specific Detection with ICP-Based Techniques2.3.2 Electrospray Ionization-Mass Spectrometry (ESI-MS); 2.3.3 Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Techniques (MALDI-MS); 2.4 Overview about Coupling Techniques; 2.4.1 LC Couplings; 2.4.2 Coupling of CE and ICP-MS; 2.4.3 Laser Ablation (LA); 2.4.4 Gas Chromatography (GC); 2.5 Final Remarks and Outlook; References; Chapter 3 Quality Control in Speciation Analysis Using HPLC with ICP-MS and ESI MS/MS: Focus on Quantitation Strategies Using Isotope Dilution Analysis; 3.1 Introduction 327 $a3.2 Synergetic Use of Elemental and Organic Mass Spectrometry in Compound Quantitation and Quality Assurance of Food Selenium Speciation3.2.1 Quality Assurance in Species Quantitation; 3.2.2 Quality Assurance in Species Identification; 3.3 The Role of Species-Specific Isotope Dilution in Increasing Metrological Traceability for the Quantification of Bioinorganic Species; 3.3.1 IDMS and Speciation Analysis; 3.3.2 Quantitative Se Speciation in Food/Supplements by Species-Specific IDMS: Production of ""Speciated"" Reference Materials 327 $a3.3.3 Species-Specific Double IDMS Quantification of Plasma Selenoproteins: Advantages and Limitations in Comparison with the Species-Unspecific IDMS Approach3.3.4 Application of Species-Specific Double Spike IDMS to Account for Redox Exchange between Cr(III) and Cr(VI) Species: Practical Considerations for Quality Assurance; References; Chapter 4 Novel Methods for Bioimaging Including LA-ICP-MS, NanoSIMS, TEM/X-EDS, and SXRF; 4.1 Introduction; 4.2 Bioimaging by LA-ICP-MS; 4.2.1 Principle; 4.2.2 Elemental Bioimaging by LA-ICP-MS; 4.2.3 Quantitative Bioimaging by LA-ICP-MS 327 $a4.2.4 Proteomic Bioimaging by LA-ICP-MS 330 $aLatest developments, new insights and knowledge derived from speciation analysis in one unique compilation: The reader gets acquainted with relevant instrumental as well as application aspects of metallomics approaches, paving the road to understanding fate, pathway, and action of metals in environment and organisms. Upon an introductory chapter on analytical methods and strategies, the full bandwidth of applications is discussed. Expert chapter authors cast spotlights on recent topics such as metallomics applications to environmental and nutrition studies as well as biology and medicine. Special chapters deal with the impact of manganese and iron on neurodegeneration, and the impact of nanoparticles on health. 606 $aMetals$xPhysiological effect 610 $aProteins 610 $aScience 615 0$aMetals$xPhysiological effect. 676 $a338.4779102854678 702 $aMichalke$b Bernhard 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830000203321 996 $aMetallomics$91960579 997 $aUNINA