Discrimination of Mobile Supramolecular Chirality : Acylative Molecular Transformations by Organocatalysis / / by Ayumi Imayoshi
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| Autore: |
Imayoshi Ayumi
|
| Titolo: |
Discrimination of Mobile Supramolecular Chirality : Acylative Molecular Transformations by Organocatalysis / / by Ayumi Imayoshi
|
| Pubblicazione: | Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2022 |
| Edizione: | 1st ed. 2022. |
| Descrizione fisica: | 1 online resource (99 pages) |
| Disciplina: | 541.226 |
| Soggetto topico: | Chemistry, Organic |
| Catalysis | |
| Nanotechnology | |
| Clinical biochemistry | |
| Organic Chemistry | |
| Medical Biochemistry | |
| Nota di contenuto: | Introduction -- Mechanistic Study of Organocatalytic Chemoselective Monoacylation of 1,5-Pentanediol -- Discrimination of Mobile Supramolecular Chirality: Kinetic Resolution of Topologically Chiral Racemic Rotaxanes by Organocatalysis -- Conclusion and Perspective. |
| Sommario/riassunto: | This book proposes a novel concept for molecular recognition. In the field of asymmetric synthesis approaching the mature science, asymmetric discrimination and catalytic synthesis of chiral supramolecules still stand as unsolved problems. The extreme difficulty in asymmetric synthesis of such supramolecules may result from the mobile nature of supramolecular chirality. Here the author shows the first highly enantioselective synthesis of mechanically chiral supramolecules. In the presence of a chiral organocatalyst, a mechanically planar chiral rotaxane was obtained with p erfect enantiopurity (>99% ee) with an excellent selectivity. The dynamic and flexible recognition mode enabled asymmetric synthesis of supramolecules with conformational flexibility and mobility. The recognition mode of the catalyst is a contrast to the traditional static and rigid recognition mode of the typical conventional catalysts. The concept of dynamic molecular recognition will be adopted as a novel concept in a wide range of fields beyond the field of organic chemistry, including material chemistry, biochemistry, and medicinal chemistry. |
| Titolo autorizzato: | Discrimination of Mobile Supramolecular Chirality |
| ISBN: | 981-16-7430-2 |
| 981-16-7431-0 | |
| Formato: | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione: | Inglese |
| Record Nr.: | 9910743395103321 |
| Lo trovi qui: | Univ. Federico II |
| Opac: | Controlla la disponibilità qui |
Serie:
Springer Theses, Recognizing Outstanding Ph.D. Research, . 2190-5061