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101 0 $aeng
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182   $cc$2rdamedia
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200 10$aDiscrimination of Mobile Supramolecular Chirality $eAcylative Molecular Transformations by Organocatalysis /$fby Ayumi Imayoshi
205   $a1st ed. 2022.
210  1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2022.
215   $a1 online resource (99 pages)
225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5061
311 08$aPrint version: Imayoshi, Ayumi Discrimination of Mobile Supramolecular Chirality Singapore : Springer Singapore Pte. Limited,c2021 9789811674303 
327   $aIntroduction -- Mechanistic Study of Organocatalytic Chemoselective Monoacylation of 1,5-Pentanediol -- Discrimination of Mobile Supramolecular Chirality: Kinetic Resolution of Topologically Chiral Racemic Rotaxanes by Organocatalysis -- Conclusion and Perspective.
330   $aThis book proposes a novel concept for molecular recognition. In the field of asymmetric synthesis approaching the mature science, asymmetric discrimination and catalytic synthesis of chiral supramolecules still stand as unsolved problems. The extreme difficulty in asymmetric synthesis of such supramolecules may result from the mobile nature of supramolecular chirality. Here the author shows the first highly enantioselective synthesis of mechanically chiral supramolecules. In the presence of a chiral organocatalyst, a mechanically planar chiral rotaxane was obtained with p erfect enantiopurity (>99% ee) with an excellent selectivity. The dynamic and flexible recognition mode enabled asymmetric synthesis of supramolecules with conformational flexibility and mobility. The recognition mode of the catalyst is a contrast to the traditional static and rigid recognition mode of the typical conventional catalysts. The concept of dynamic molecular recognition will be adopted as a novel concept in a wide range of fields beyond the field of organic chemistry, including material chemistry, biochemistry, and medicinal chemistry.
410  0$aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5061
606   $aChemistry, Organic
606   $aCatalysis
606   $aNanotechnology
606   $aClinical biochemistry
606   $aOrganic Chemistry
606   $aCatalysis
606   $aNanotechnology
606   $aMedical Biochemistry
615  0$aChemistry, Organic.
615  0$aCatalysis.
615  0$aNanotechnology.
615  0$aClinical biochemistry.
615 14$aOrganic Chemistry.
615 24$aCatalysis.
615 24$aNanotechnology.
615 24$aMedical Biochemistry.
676   $a541.226
700   $aImayoshi$b Ayumi$01077385
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910743395103321
996   $aDiscrimination of Mobile Supramolecular Chirality$92588761
997   $aUNINA