03566nam 22006735 450 991074339510332120251204110604.0981-16-7430-2981-16-7431-0981-16-7431-010.1007/978-981-16-7431-0(MiAaPQ)EBC6810941(Au-PeEL)EBL6810941(CKB)19919344300041(OCoLC)1287130633(PPN)258840471(BIP)81700825(DE-He213)978-981-16-7431-0(EXLCZ)991991934430004120211118d2022 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierDiscrimination of Mobile Supramolecular Chirality Acylative Molecular Transformations by Organocatalysis /by Ayumi Imayoshi1st ed. 2022.Singapore :Springer Nature Singapore :Imprint: Springer,2022.1 online resource (99 pages)Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5061Print version: Imayoshi, Ayumi Discrimination of Mobile Supramolecular Chirality Singapore : Springer Singapore Pte. Limited,c2021 9789811674303 Introduction -- Mechanistic Study of Organocatalytic Chemoselective Monoacylation of 1,5-Pentanediol -- Discrimination of Mobile Supramolecular Chirality: Kinetic Resolution of Topologically Chiral Racemic Rotaxanes by Organocatalysis -- Conclusion and Perspective.This book proposes a novel concept for molecular recognition. In the field of asymmetric synthesis approaching the mature science, asymmetric discrimination and catalytic synthesis of chiral supramolecules still stand as unsolved problems. The extreme difficulty in asymmetric synthesis of such supramolecules may result from the mobile nature of supramolecular chirality. Here the author shows the first highly enantioselective synthesis of mechanically chiral supramolecules. In the presence of a chiral organocatalyst, a mechanically planar chiral rotaxane was obtained with p erfect enantiopurity (>99% ee) with an excellent selectivity. The dynamic and flexible recognition mode enabled asymmetric synthesis of supramolecules with conformational flexibility and mobility. The recognition mode of the catalyst is a contrast to the traditional static and rigid recognition mode of the typical conventional catalysts. The concept of dynamic molecular recognition will be adopted as a novel concept in a wide range of fields beyond the field of organic chemistry, including material chemistry, biochemistry, and medicinal chemistry.Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5061Chemistry, OrganicCatalysisNanotechnologyClinical biochemistryOrganic ChemistryCatalysisNanotechnologyMedical BiochemistryChemistry, Organic.Catalysis.Nanotechnology.Clinical biochemistry.Organic Chemistry.Catalysis.Nanotechnology.Medical Biochemistry.541.226Imayoshi Ayumi1077385MiAaPQMiAaPQMiAaPQBOOK9910743395103321Discrimination of Mobile Supramolecular Chirality2588761UNINA