Pathogenic Escherichia coli : molecular and cellular microbiology / / edited by Stefano Morabito

• Pubblicazione: Norfolk, England : , : Caister Academic Press, , [2014]; ©2014
• Descrizione fisica: 1 online resource (316 p.)
• Disciplina: 589.95
• Soggetto topico: Escherichia coli; Microbiology; Pathogenic microorganisms
• Soggetto genere / forma: Electronic books.
• Persona (resp. second.): MorabitoStefano (Molecular microbiologist)
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Contents; Contributors; Foreword; 1: Diarrhoeagenic Escherichia coli Infections in Humans; Introduction; Enteropathogenic E. coli (EPEC); Enterotoxigenic E. coli (ETEC); Enteroinvasive E. coli (EIEC); Enteroaggregative E. coli (EAggEC); Diffusely adherent E. coli (DAEC); Shiga toxin-producing E. coli (STEC) or verocytotoxin-producing E. coli (VTEC); 2: Pathogenic Escherichia coli in Domestic Mammals and Birds; Classification of pathogenic Escherichia coli; Diarrhoeagenic Escherichia coli; Enterotoxaemic Escherichia coli; Extraintestinal Escherichia coli; Concluding remarks ; 3: Genomic Plasticity and the Emergence of New Pathogenic Escherichia coliIntroduction; Genome structure of extraintestinal and intestinal pathogenic E. coli; Mobile elements; Genome alterations during human infections - a model of real-time pathogen evolution; 4: Shiga Toxin-encoding Phages: Multifunctional Gene Ferries; General overview on Stx-phages; History and general description of Stx-phages; Diversity of Stx-phages; Genome structure of Stx-phages; Structure of the stx region; Stx-phage induction and its role in Stx production; Stx transduction and the emergence of new pathogens ; New pathogenic serotypes, outbreaks in Norway and GermanyThe impact of multiple Stx-phages in the same genome; Stx2-phages in the environment, difficulties to evaluate the presence of lytic Stx2-phages; Biological impact of Stx-phages; Conclusions; 5: Shiga Toxins; Discovery of Shiga toxins; Genetic and environmental regulation of Shiga toxin production; Shiga toxin structure; Shiga toxin receptor(s); Toxin internalization and retrograde transport; Retro-translocation; Shiga toxin-induced apoptosis; Inhibition of protein synthesis and intoxication; Shiga toxin-induced cytokine synthesis ; Pathophysiology of organ damageIntervention strategies; Biomedical applications of Shiga toxins; Conclusions and future directions; 6: Escherichia coli Subtilase Cytotoxin: Structure, Function and Role in Disease; Introduction; Biological characterization; Cytotoxic mechanism; Receptor binding; Intracellular trafficking; Strain distribution of SubAB and identification of allelic variants; Pathological features and immune modulation; Role in disease; Conclusions; 7: Cell Cycle Modulating Toxins Produced by Escherichia coli; Cytotoxic necrotizing factor (CNF); Cytolethal distending toxins ; Cycle inhibiting factors (Cif)Colibactin; Conclusion; 8: The Heat-stable and Heat-labile Enterotoxins Produced by Enterotoxigenic Escherichia coli; Introduction; Heat-stable enterotoxin; Heat-labile enterotoxin; Conclusion; 9: Haemolysins; The HlyA protein; HlyA mechanism of action; HlyA role in virulence; Extracellular export of HlyA; Post-translational modification of HlyA; Genetics and regulation of hlyA expression; The EHEC haemolysin; The EHEC-Hly gene locus, its conservation and regulation; EHEC-Hly mechanism of action and role in pathogenesis; The ClyA (SheA, HlyE) protein ; Mechanism of action of ClyA
• Sommario/riassunto: In recent years, a great deal of knowledge has accumulated on the features associated with the virulence of pathogenic E. coli. A large number of virulence genes have been identified and their products characterized. Great strides have been made in the understanding of the pathogenic mechanisms and the bacterium-host interaction. However, much remains elusive in the understanding of pathogenicity at a cellular and sub-cellular level. This is largely due to E. coli genome's plasticity: it generates great variability and facilitates the rapid emergence of new pathogenic variants. Elucidating the
• Titolo autorizzato: Pathogenic Escherichia coli
• ISBN: 1-908230-99-1
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910464438403321
• Lo trovi qui: Univ. Federico II