LEADER 05338nam 2200637 450 001 9910464438403321 005 20191011064649.0 010 $a1-908230-99-1 035 $a(CKB)3710000000088748 035 $a(EBL)1899234 035 $a(SSID)ssj0001165452 035 $a(PQKBManifestationID)11679840 035 $a(PQKBTitleCode)TC0001165452 035 $a(PQKBWorkID)11197839 035 $a(PQKB)10439255 035 $a(MiAaPQ)EBC1899234 035 $a(MiAaPQ)EBC5897780 035 $a(Au-PeEL)EBL5897780 035 $a(OCoLC)872563547 035 $a(EXLCZ)993710000000088748 100 $a20191011d2014 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aPathogenic Escherichia coli $emolecular and cellular microbiology /$fedited by Stefano Morabito 210 1$aNorfolk, England :$cCaister Academic Press,$d[2014] 210 4$dİ2014 215 $a1 online resource (316 p.) 300 $aDescription based upon print version of record. 311 $a1-908230-37-1 320 $aIncludes bibliographical references and index. 327 $aContents; Contributors; Foreword; 1: Diarrhoeagenic Escherichia coli Infections in Humans; Introduction; Enteropathogenic E. coli (EPEC); Enterotoxigenic E. coli (ETEC); Enteroinvasive E. coli (EIEC); Enteroaggregative E. coli (EAggEC); Diffusely adherent E. coli (DAEC); Shiga toxin-producing E. coli (STEC) or verocytotoxin-producing E. coli (VTEC); 2: Pathogenic Escherichia coli in Domestic Mammals and Birds; Classification of pathogenic Escherichia coli; Diarrhoeagenic Escherichia coli; Enterotoxaemic Escherichia coli; Extraintestinal Escherichia coli; Concluding remarks 327 $a3: Genomic Plasticity and the Emergence of New Pathogenic Escherichia coliIntroduction; Genome structure of extraintestinal and intestinal pathogenic E. coli; Mobile elements; Genome alterations during human infections - a model of real-time pathogen evolution; 4: Shiga Toxin-encoding Phages: Multifunctional Gene Ferries; General overview on Stx-phages; History and general description of Stx-phages; Diversity of Stx-phages; Genome structure of Stx-phages; Structure of the stx region; Stx-phage induction and its role in Stx production; Stx transduction and the emergence of new pathogens 327 $aNew pathogenic serotypes, outbreaks in Norway and GermanyThe impact of multiple Stx-phages in the same genome; Stx2-phages in the environment, difficulties to evaluate the presence of lytic Stx2-phages; Biological impact of Stx-phages; Conclusions; 5: Shiga Toxins; Discovery of Shiga toxins; Genetic and environmental regulation of Shiga toxin production; Shiga toxin structure; Shiga toxin receptor(s); Toxin internalization and retrograde transport; Retro-translocation; Shiga toxin-induced apoptosis; Inhibition of protein synthesis and intoxication; Shiga toxin-induced cytokine synthesis 327 $aPathophysiology of organ damageIntervention strategies; Biomedical applications of Shiga toxins; Conclusions and future directions; 6: Escherichia coli Subtilase Cytotoxin: Structure, Function and Role in Disease; Introduction; Biological characterization; Cytotoxic mechanism; Receptor binding; Intracellular trafficking; Strain distribution of SubAB and identification of allelic variants; Pathological features and immune modulation; Role in disease; Conclusions; 7: Cell Cycle Modulating Toxins Produced by Escherichia coli; Cytotoxic necrotizing factor (CNF); Cytolethal distending toxins 327 $aCycle inhibiting factors (Cif)Colibactin; Conclusion; 8: The Heat-stable and Heat-labile Enterotoxins Produced by Enterotoxigenic Escherichia coli; Introduction; Heat-stable enterotoxin; Heat-labile enterotoxin; Conclusion; 9: Haemolysins; The HlyA protein; HlyA mechanism of action; HlyA role in virulence; Extracellular export of HlyA; Post-translational modification of HlyA; Genetics and regulation of hlyA expression; The EHEC haemolysin; The EHEC-Hly gene locus, its conservation and regulation; EHEC-Hly mechanism of action and role in pathogenesis; The ClyA (SheA, HlyE) protein 327 $aMechanism of action of ClyA 330 $aIn recent years, a great deal of knowledge has accumulated on the features associated with the virulence of pathogenic E. coli. A large number of virulence genes have been identified and their products characterized. Great strides have been made in the understanding of the pathogenic mechanisms and the bacterium-host interaction. However, much remains elusive in the understanding of pathogenicity at a cellular and sub-cellular level. This is largely due to E. coli genome's plasticity: it generates great variability and facilitates the rapid emergence of new pathogenic variants. Elucidating the 606 $aEscherichia coli 606 $aMicrobiology 606 $aPathogenic microorganisms 608 $aElectronic books. 615 0$aEscherichia coli. 615 0$aMicrobiology. 615 0$aPathogenic microorganisms. 676 $a589.95 702 $aMorabito$b Stefano$c(Molecular microbiologist), 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910464438403321 996 $aPathogenic Escherichia coli$92195745 997 $aUNINA