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Calcitonin Gene-Related Peptide (CGRP) Mechanisms : Focus on Migraine / / edited by Susan D. Brain, Pierangelo Geppetti



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Titolo: Calcitonin Gene-Related Peptide (CGRP) Mechanisms : Focus on Migraine / / edited by Susan D. Brain, Pierangelo Geppetti Visualizza cluster
Pubblicazione: Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019
Edizione: 1st ed. 2019.
Descrizione fisica: 1 online resource (198 pages) : illustrations
Disciplina: 616.857
616.84912
Soggetto topico: Pharmacology
Neurology 
Pain medicine
Neurosciences
Pharmacology/Toxicology
Neurology
Pain Medicine
Persona (resp. second.): BrainSusan D
GeppettiPierangelo
Nota di contenuto: 1. CGRP Discovery and Timeline -- 2. CGRP Receptor Biology: Is There More Than One Receptor? -- 3. The Structure of the CGRP and Related Receptors -- 4. CGRP Receptor Signalling Pathways -- 5. Pathways of CGRP Release from Primary Sensory Neurons -- 6. CGRP in Animal Models of Migraine -- 7. CGRP in Human Models of Migraine -- 8. Role of CGRP in Migraine -- 9. Understanding CGRP and Cardiovascular Risk -- 10. CGRP and Painful Pathologies other than Headache -- 11. Calcitonin Gene-Related Peptide Antagonists and Therapeutic Antibodies.
Sommario/riassunto: This book is designed to focus on the role of Calcitonin Gene-Related Peptide (CGRP) in health and disease. This peptide, originally discovered in the 1980s as a sensory neuropeptide with cardiovascular effects, is now known to play a distinct role in the pain processing of migraine. The various chapters address the origin, localization and function of CGRP and its receptor in the peripheral nervous system, in the cardiovascular system, and in other tissues and organs. Further attention is paid to the drug discovery pathway where recent findings show the beneficial effect of small molecule antagonists of the CGRP receptors for the relief of the migraine attack and of monoclonal antibodies against CGRP or the CGRP receptor for migraine prevention. .
Titolo autorizzato: Calcitonin gene-related peptide (CGRP) mechanisms  Visualizza cluster
ISBN: 3-030-21454-0
Formato: Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione: Inglese
Record Nr.: 9910349285403321
Lo trovi qui: Univ. Federico II
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Serie: Handbook of Experimental Pharmacology, . 0171-2004 ; ; 255