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101 0 $aeng
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181   $ctxt$2rdacontent
182   $cc$2rdamedia
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200 10$aCalcitonin Gene-Related Peptide (CGRP) Mechanisms $eFocus on Migraine /$fedited by Susan D. Brain, Pierangelo Geppetti
205   $a1st ed. 2019.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2019.
215   $a1 online resource (198 pages) $cillustrations
225 1 $aHandbook of Experimental Pharmacology,$x0171-2004 ;$v255
311   $a3-030-21453-2 
327   $a1. CGRP Discovery and Timeline -- 2. CGRP Receptor Biology: Is There More Than One Receptor? -- 3. The Structure of the CGRP and Related Receptors -- 4. CGRP Receptor Signalling Pathways -- 5. Pathways of CGRP Release from Primary Sensory Neurons -- 6. CGRP in Animal Models of Migraine -- 7. CGRP in Human Models of Migraine -- 8. Role of CGRP in Migraine -- 9. Understanding CGRP and Cardiovascular Risk -- 10. CGRP and Painful Pathologies other than Headache -- 11. Calcitonin Gene-Related Peptide Antagonists and Therapeutic Antibodies.
330   $aThis book is designed to focus on the role of Calcitonin Gene-Related Peptide (CGRP) in health and disease. This peptide, originally discovered in the 1980s as a sensory neuropeptide with cardiovascular effects, is now known to play a distinct role in the pain processing of migraine. The various chapters address the origin, localization and function of CGRP and its receptor in the peripheral nervous system, in the cardiovascular system, and in other tissues and organs. Further attention is paid to the drug discovery pathway where recent findings show the beneficial effect of small molecule antagonists of the CGRP receptors for the relief of the migraine attack and of monoclonal antibodies against CGRP or the CGRP receptor for migraine prevention. .
410  0$aHandbook of Experimental Pharmacology,$x0171-2004 ;$v255
606   $aPharmacology
606   $aNeurology
606   $aPain medicine
606   $aNeurosciences
606   $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007
606   $aNeurology$3https://scigraph.springernature.com/ontologies/product-market-codes/H36001
606   $aPain Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/H47003
606   $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006
615  0$aPharmacology.
615  0$aNeurology.
615  0$aPain medicine.
615  0$aNeurosciences.
615 14$aPharmacology/Toxicology.
615 24$aNeurology.
615 24$aPain Medicine.
615 24$aNeurosciences.
676   $a616.857
676   $a616.84912
702   $aBrain$b Susan D$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aGeppetti$b Pierangelo$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
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996   $aCalcitonin gene-related peptide (CGRP) mechanisms$91766348
997   $aUNINA