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Record Nr. |
UNINA9910349285403321 |
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Titolo |
Calcitonin Gene-Related Peptide (CGRP) Mechanisms : Focus on Migraine / / edited by Susan D. Brain, Pierangelo Geppetti |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 |
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ISBN |
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Edizione |
[1st ed. 2019.] |
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Descrizione fisica |
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1 online resource (198 pages) : illustrations |
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Collana |
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Handbook of Experimental Pharmacology, , 0171-2004 ; ; 255 |
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Disciplina |
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Soggetti |
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Pharmacology |
Neurology |
Pain medicine |
Neurosciences |
Pharmacology/Toxicology |
Neurology |
Pain Medicine |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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1. CGRP Discovery and Timeline -- 2. CGRP Receptor Biology: Is There More Than One Receptor? -- 3. The Structure of the CGRP and Related Receptors -- 4. CGRP Receptor Signalling Pathways -- 5. Pathways of CGRP Release from Primary Sensory Neurons -- 6. CGRP in Animal Models of Migraine -- 7. CGRP in Human Models of Migraine -- 8. Role of CGRP in Migraine -- 9. Understanding CGRP and Cardiovascular Risk -- 10. CGRP and Painful Pathologies other than Headache -- 11. Calcitonin Gene-Related Peptide Antagonists and Therapeutic Antibodies. |
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Sommario/riassunto |
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This book is designed to focus on the role of Calcitonin Gene-Related Peptide (CGRP) in health and disease. This peptide, originally discovered in the 1980s as a sensory neuropeptide with cardiovascular effects, is now known to play a distinct role in the pain processing of migraine. The various chapters address the origin, localization and function of CGRP and its receptor in the peripheral nervous system, in |
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