Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C−H Bonds / / by Stacey L. McDonald
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| Autore: |
McDonald Stacey L
|
| Titolo: |
Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C−H Bonds / / by Stacey L. McDonald
|
| Pubblicazione: | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 |
| Edizione: | 1st ed. 2016. |
| Descrizione fisica: | 1 online resource (XXIII, 144 p. 8 illus.) |
| Disciplina: | 546.652595 |
| Soggetto topico: | Organometallic chemistry |
| Medicinal chemistry | |
| Chemical engineering | |
| Organometallic Chemistry | |
| Medicinal Chemistry | |
| Industrial Chemistry/Chemical Engineering | |
| Nota di bibliografia: | Includes bibliographical references at the end of each chapters. |
| Nota di contenuto: | Electrophilic amination for the synthesis of alkyl and aryl amines -- Selective α-amination and α-acylation of esters and amides via dual reactivity of O-acylhydroxylamines toward zinc enolates -- Copper-catalyzed α-amination of phosphonates and phosphine oxides: a direct approach to α-amino phosphonic acids and derivatives -- Copper-Catalyzed Electrophilic Amination of Heteroarenes and Arenes by C−H Zincation. |
| Sommario/riassunto: | This thesis reports the latest developments in the direct amination of various C−H bonds using an H−Zn exchange/electrophilic amination strategy. McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines. The material outlined in this book shows how McDonald achieved C−H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source. McDonald’s findings are of relevance to medicinal chemistry, drug discovery and materials science. Her thesis is a source of inspiration for scientists entering the field and students beginning their PhD in a related area. . |
| Titolo autorizzato: | Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C−H Bonds |
| ISBN: | 3-319-38878-9 |
| Formato: | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione: | Inglese |
| Record Nr.: | 9910254039003321 |
| Lo trovi qui: | Univ. Federico II |
| Opac: | Controlla la disponibilità qui |
Serie:
Springer Theses, Recognizing Outstanding Ph.D. Research, . 2190-5053