LEADER 03443nam 22005775 450 001 9910254039003321 005 20200701223729.0 010 $a3-319-38878-9 024 7 $a10.1007/978-3-319-38878-6 035 $a(CKB)3710000000831560 035 $a(DE-He213)978-3-319-38878-6 035 $a(MiAaPQ)EBC4648909 035 $a(PPN)19480514X 035 $a(EXLCZ)993710000000831560 100 $a20160818d2016 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCopper-Catalyzed Electrophilic Amination of sp2 and sp3 C?H Bonds /$fby Stacey L. McDonald 205 $a1st ed. 2016. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2016. 215 $a1 online resource (XXIII, 144 p. 8 illus.) 225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053 311 $a3-319-38877-0 320 $aIncludes bibliographical references at the end of each chapters. 327 $aElectrophilic amination for the synthesis of alkyl and aryl amines -- Selective ?-amination and ?-acylation of esters and amides via dual reactivity of O-acylhydroxylamines toward zinc enolates -- Copper-catalyzed ?-amination of phosphonates and phosphine oxides: a direct approach to ?-amino phosphonic acids and derivatives -- Copper-Catalyzed Electrophilic Amination of Heteroarenes and Arenes by C?H Zincation. 330 $aThis thesis reports the latest developments in the direct amination of various C?H bonds using an H?Zn exchange/electrophilic amination strategy. McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines. The material outlined in this book shows how McDonald achieved C?H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source. McDonald?s findings are of relevance to medicinal chemistry, drug discovery and materials science. Her thesis is a source of inspiration for scientists entering the field and students beginning their PhD in a related area. . 410 0$aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053 606 $aOrganometallic chemistry  606 $aMedicinal chemistry 606 $aChemical engineering 606 $aOrganometallic Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C19020 606 $aMedicinal Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C28000 606 $aIndustrial Chemistry/Chemical Engineering$3https://scigraph.springernature.com/ontologies/product-market-codes/C27000 615 0$aOrganometallic chemistry . 615 0$aMedicinal chemistry. 615 0$aChemical engineering. 615 14$aOrganometallic Chemistry. 615 24$aMedicinal Chemistry. 615 24$aIndustrial Chemistry/Chemical Engineering. 676 $a546.652595 700 $aMcDonald$b Stacey L$4aut$4http://id.loc.gov/vocabulary/relators/aut$01062349 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910254039003321 996 $aCopper-Catalyzed Electrophilic Amination of sp2 and sp3 C?H Bonds$92524475 997 $aUNINA