00798nam a2200241 i 450099100092410970753620020502181131.0941124s1992 it ||| | ita 8804361891b11437704-39ule_instPRUMB51558ExLDip. SSSC - DIDATTICAitaMehler, Jacques198375Appena nato /Jacques MehlerMilano :Mondadori,1992260 p. :ill. ;23 cm.Saggi [Mondadori].b1143770401-03-1701-07-02991000924109707536LE021 DI1A1011LE021N-11573le021-E0.00-l- 00000.i1162243x01-07-02Appena nato818926UNISALENTOle02101-01-94ma -itait 0103449nam 22005775 450 991025403900332120200701223729.03-319-38878-910.1007/978-3-319-38878-6(CKB)3710000000831560(DE-He213)978-3-319-38878-6(MiAaPQ)EBC4648909(PPN)19480514X(EXLCZ)99371000000083156020160818d2016 u| 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierCopper-Catalyzed Electrophilic Amination of sp2 and sp3 C−H Bonds /by Stacey L. McDonald1st ed. 2016.Cham :Springer International Publishing :Imprint: Springer,2016.1 online resource (XXIII, 144 p. 8 illus.) Springer Theses, Recognizing Outstanding Ph.D. Research,2190-50533-319-38877-0 Includes bibliographical references at the end of each chapters.Electrophilic amination for the synthesis of alkyl and aryl amines -- Selective α-amination and α-acylation of esters and amides via dual reactivity of O-acylhydroxylamines toward zinc enolates -- Copper-catalyzed α-amination of phosphonates and phosphine oxides: a direct approach to α-amino phosphonic acids and derivatives -- Copper-Catalyzed Electrophilic Amination of Heteroarenes and Arenes by C−H Zincation.This thesis reports the latest developments in the direct amination of various C−H bonds using an H−Zn exchange/electrophilic amination strategy. McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines. The material outlined in this book shows how McDonald achieved C−H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source. McDonald’s findings are of relevance to medicinal chemistry, drug discovery and materials science. Her thesis is a source of inspiration for scientists entering the field and students beginning their PhD in a related area. .Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053Organometallic chemistryPharmaceutical chemistryChemical engineeringOrganometallic Chemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/C19020Medicinal Chemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/C28000Industrial Chemistry/Chemical Engineeringhttps://scigraph.springernature.com/ontologies/product-market-codes/C27000Organometallic chemistry.Pharmaceutical chemistry.Chemical engineering.Organometallic Chemistry.Medicinal Chemistry.Industrial Chemistry/Chemical Engineering.546.652595McDonald Stacey Lauthttp://id.loc.gov/vocabulary/relators/aut1062349MiAaPQMiAaPQMiAaPQBOOK9910254039003321Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C−H Bonds2524475UNINA