Chemistry of bioconjugates : synthesis, characterization, and biomedical applications / / edited by Ravin Narain

• Pubblicazione: Hoboken, New Jersey : , : Wiley, , 2014; ©2014
• Descrizione fisica: 1 online resource (495 p.)
• Disciplina: 612.1/111
• Soggetto topico: Bioconjugates
• Altri autori: NarainRavin
• Note generali: Includes index.
• Nota di bibliografia: Includes bibliographical references at the end of each chapters and index.
• Nota di contenuto: CHEMISTRY OF BIOCONJUGATES; CONTENTS; PREFACE; CONTRIBUTORS; SECTION I GENERAL METHODS OF BIOCONJUGATION; 1 COVALENT AND NONCOVALENT BIOCONJUGATION STRATEGIES; 1.1 INTRODUCTION; 1.2 COVALENT BIOCONJUGATION STRATEGIES; 1.2.1 Carboxyl Modifications; 1.2.2 Carbonyl Functional Groups; 1.2.3 Amine Modifications; 1.2.4 Thiol Modifications; 1.2.5 Hydroxyl Modifications; 1.2.6 Native Chemical Ligation and Expressed Protein Ligation; 1.2.7 Cross-linking Reagents for Bioconjugation; 1.2.8 Bioorthogonal Reactions; 1.2.9 Bioconjugation Via Transition Metal-catalyzed/Mediated Reactions ; 1.2.10 Other Covalent Bioconjugation Methods1.3 NONCOVALENT BIOCONJUGATION STRATEGIES; 1.3.1 Biotin-(Strept)Avidin System; 1.3.2 Electrostatic Interactions; 1.3.3 Metal-mediated Non-covalent Conjugation; 1.3.4 Hybridization Method; 1.4 CONCLUSIONS AND OUTLOOK; REFERENCES; SECTION II POLYMER BIOCONJUGATES; 2 BIOCONJUGATES BASED ON POLY(ETHYLENE GLYCOL)S AND POLYGLYCEROLS; 2.1 INTRODUCTION; 2.2 POLYETHYLENE GLYCOL-BASED BIOCONJUGATES; 2.2.1 PEG-protein Conjugates; 2.2.2 PEG-peptide Conjugates; 2.2.3 PEG-antibody Conjugates; 2.2.4 PEGylation of Cells and Tissues ; 2.2.5 PEG Conjugates of Oligonucleotides, Aptamers, and siRNAs2.2.6 PEG-drug Conjugates (PEG prodrugs); 2.2.7 PEGylation of Viruses; 2.3 LIMITATIONS OF PEG CONJUGATES; 2.4 POLYGLYCEROL-BASED CONJUGATES; 2.4.1 HPG-drug Conjugates; 2.4.2 HPG-peptide and Protein Conjugates; 2.4.3 HPG Glycoconjugates; 2.4.4 HPG-Red Blood Cell Conjugates for Antigen Protection; 2.5 CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; 3 SYNTHETIC POLYMER BIOCONJUGATE SYSTEMS; 3.1 INTRODUCTION; 3.2 PEPTIDE OR PROTEIN BIOCONJUGATION TECHNIQUES; 3.2.1 Conjugation with Amino Acid; 3.2.2 Conjugation with Peptide Chain ; 3.2.3 Conjugation with Proteins3.3 CARBOHYDRATE BIOCONJUGATION TECHNIQUES; 3.4 CONJUGATION WITH NUCLEIC ACID; 3.5 CONJUGATION WITH DRUGS; 3.6 CONJUGATION WITH CONTRAST AGENTS; 3.6.1 Polymers for Magnetic Resonance Imaging; 3.6.2 Polymers for Optical Imaging; 3.6.3 Polymers for Nuclear imaging; 3.7 CONCLUSION AND PERSPECTIVE; REFERENCES; 4 NATURAL POLYMER BIOCONJUGATE SYSTEMS; 4.1 INTRODUCTION; 4.2 NATURAL POLYMER SYSTEMS; 4.2.1 Protein-origin Polymer Bioconjugates; 4.2.2 Polysaccharidic Polymer Bioconjugates; 4.3 CONCLUSION AND FUTURE DIRECTIONS; ACKNOWLEDGMENT; REFERENCES ; 5 DENDRIMER BIOCONJUGATES: SYNTHESIS AND APPLICATIONS5.1 INTRODUCTION-DENDRIMERS FOR BIOCONJUGATE CHEMISTRY; 5.2 DENDRIMER-DRUG CONJUGATES; 5.2.1 Motivation for the Development of Dendrimer-Drug Conjugates; 5.2.2 Dendrimer-DOX Conjugates; 5.2.3 Dendrimer-MTX Conjugates; 5.2.4 Dendrimer-TAX Conjugates; 5.2.5 Dendrimer-NAC Conjugates; 5.2.6 Dendrimer-Sulfonic Acids; 5.3 DENDRIMER-CARBOHYDRATE CONJUGATES; 5.3.1 Motivation for the Development of Dendrimer-Carbohydrate Conjugates; 5.3.2 Dendrimer-Mannose Conjugates; 5.3.3 Dendrimer-Galactose Conjugates; 5.3.4 Dendrimer-AcNA Conjugates ; 5.4 DENDRIMER CONJUGATES WITH IMAGING AGENTS
• Sommario/riassunto: This book describes the chemistries involved in bioconjugation followed by an extensive review of all types of bioconjugates (polymers, dendrimers, nanoparticles, carbon nanotubes) reported in the literature for different bio-related applications. A section is devoted to the physico-chemical and biochemical properties of bioconjugates and implications in their uses. Finally, the book also provides a comprehensive account about the significance of bioconjugation - coverage that is lacking in many of the current resources available.
• Titolo autorizzato: Chemistry of bioconjugates
• ISBN: 1-118-77637-2; 1-118-77588-0; 1-118-77640-2
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910140188603321
• Lo trovi qui: Univ. Federico II