05164nam 2200625 450 991014018860332120230803195022.01-118-77637-21-118-77588-01-118-77640-2(CKB)2670000000494070(EBL)1574607(SSID)ssj0001060703(PQKBManifestationID)11695220(PQKBTitleCode)TC0001060703(PQKBWorkID)11087401(PQKB)11609725(MiAaPQ)EBC1574607(DLC) 2013027519(Au-PeEL)EBL1574607(CaPaEBR)ebr10814700(CaONFJC)MIL550381(OCoLC)865332098(EXLCZ)99267000000049407020131223d2014 uy 0engur|n|---|||||txtccrChemistry of bioconjugates synthesis, characterization, and biomedical applications /edited by Ravin NarainHoboken, New Jersey :Wiley,2014.©20141 online resource (495 p.)Includes index.1-118-35914-3 Includes bibliographical references at the end of each chapters and index.CHEMISTRY OF BIOCONJUGATES; CONTENTS; PREFACE; CONTRIBUTORS; SECTION I GENERAL METHODS OF BIOCONJUGATION; 1 COVALENT AND NONCOVALENT BIOCONJUGATION STRATEGIES; 1.1 INTRODUCTION; 1.2 COVALENT BIOCONJUGATION STRATEGIES; 1.2.1 Carboxyl Modifications; 1.2.2 Carbonyl Functional Groups; 1.2.3 Amine Modifications; 1.2.4 Thiol Modifications; 1.2.5 Hydroxyl Modifications; 1.2.6 Native Chemical Ligation and Expressed Protein Ligation; 1.2.7 Cross-linking Reagents for Bioconjugation; 1.2.8 Bioorthogonal Reactions; 1.2.9 Bioconjugation Via Transition Metal-catalyzed/Mediated Reactions1.2.10 Other Covalent Bioconjugation Methods1.3 NONCOVALENT BIOCONJUGATION STRATEGIES; 1.3.1 Biotin-(Strept)Avidin System; 1.3.2 Electrostatic Interactions; 1.3.3 Metal-mediated Non-covalent Conjugation; 1.3.4 Hybridization Method; 1.4 CONCLUSIONS AND OUTLOOK; REFERENCES; SECTION II POLYMER BIOCONJUGATES; 2 BIOCONJUGATES BASED ON POLY(ETHYLENE GLYCOL)S AND POLYGLYCEROLS; 2.1 INTRODUCTION; 2.2 POLYETHYLENE GLYCOL-BASED BIOCONJUGATES; 2.2.1 PEG-protein Conjugates; 2.2.2 PEG-peptide Conjugates; 2.2.3 PEG-antibody Conjugates; 2.2.4 PEGylation of Cells and Tissues2.2.5 PEG Conjugates of Oligonucleotides, Aptamers, and siRNAs2.2.6 PEG-drug Conjugates (PEG prodrugs); 2.2.7 PEGylation of Viruses; 2.3 LIMITATIONS OF PEG CONJUGATES; 2.4 POLYGLYCEROL-BASED CONJUGATES; 2.4.1 HPG-drug Conjugates; 2.4.2 HPG-peptide and Protein Conjugates; 2.4.3 HPG Glycoconjugates; 2.4.4 HPG-Red Blood Cell Conjugates for Antigen Protection; 2.5 CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; 3 SYNTHETIC POLYMER BIOCONJUGATE SYSTEMS; 3.1 INTRODUCTION; 3.2 PEPTIDE OR PROTEIN BIOCONJUGATION TECHNIQUES; 3.2.1 Conjugation with Amino Acid; 3.2.2 Conjugation with Peptide Chain3.2.3 Conjugation with Proteins3.3 CARBOHYDRATE BIOCONJUGATION TECHNIQUES; 3.4 CONJUGATION WITH NUCLEIC ACID; 3.5 CONJUGATION WITH DRUGS; 3.6 CONJUGATION WITH CONTRAST AGENTS; 3.6.1 Polymers for Magnetic Resonance Imaging; 3.6.2 Polymers for Optical Imaging; 3.6.3 Polymers for Nuclear imaging; 3.7 CONCLUSION AND PERSPECTIVE; REFERENCES; 4 NATURAL POLYMER BIOCONJUGATE SYSTEMS; 4.1 INTRODUCTION; 4.2 NATURAL POLYMER SYSTEMS; 4.2.1 Protein-origin Polymer Bioconjugates; 4.2.2 Polysaccharidic Polymer Bioconjugates; 4.3 CONCLUSION AND FUTURE DIRECTIONS; ACKNOWLEDGMENT; REFERENCES5 DENDRIMER BIOCONJUGATES: SYNTHESIS AND APPLICATIONS5.1 INTRODUCTION-DENDRIMERS FOR BIOCONJUGATE CHEMISTRY; 5.2 DENDRIMER-DRUG CONJUGATES; 5.2.1 Motivation for the Development of Dendrimer-Drug Conjugates; 5.2.2 Dendrimer-DOX Conjugates; 5.2.3 Dendrimer-MTX Conjugates; 5.2.4 Dendrimer-TAX Conjugates; 5.2.5 Dendrimer-NAC Conjugates; 5.2.6 Dendrimer-Sulfonic Acids; 5.3 DENDRIMER-CARBOHYDRATE CONJUGATES; 5.3.1 Motivation for the Development of Dendrimer-Carbohydrate Conjugates; 5.3.2 Dendrimer-Mannose Conjugates; 5.3.3 Dendrimer-Galactose Conjugates; 5.3.4 Dendrimer-AcNA Conjugates5.4 DENDRIMER CONJUGATES WITH IMAGING AGENTSThis book describes the chemistries involved in bioconjugation followed by an extensive review of all types of bioconjugates (polymers, dendrimers, nanoparticles, carbon nanotubes) reported in the literature for different bio-related applications. A section is devoted to the physico-chemical and biochemical properties of bioconjugates and implications in their uses. Finally, the book also provides a comprehensive account about the significance of bioconjugation - coverage that is lacking in many of the current resources available.BioconjugatesBioconjugates.612.1/111Narain Ravin963027MiAaPQMiAaPQMiAaPQBOOK9910140188603321Chemistry of bioconjugates2204985UNINA