LEADER 05164nam 2200625 450 001 9910140188603321 005 20230803195022.0 010 $a1-118-77637-2 010 $a1-118-77588-0 010 $a1-118-77640-2 035 $a(CKB)2670000000494070 035 $a(EBL)1574607 035 $a(SSID)ssj0001060703 035 $a(PQKBManifestationID)11695220 035 $a(PQKBTitleCode)TC0001060703 035 $a(PQKBWorkID)11087401 035 $a(PQKB)11609725 035 $a(MiAaPQ)EBC1574607 035 $a(DLC) 2013027519 035 $a(Au-PeEL)EBL1574607 035 $a(CaPaEBR)ebr10814700 035 $a(CaONFJC)MIL550381 035 $a(OCoLC)865332098 035 $a(EXLCZ)992670000000494070 100 $a20131223d2014 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aChemistry of bioconjugates $esynthesis, characterization, and biomedical applications /$fedited by Ravin Narain 210 1$aHoboken, New Jersey :$cWiley,$d2014. 210 4$dİ2014 215 $a1 online resource (495 p.) 300 $aIncludes index. 311 $a1-118-35914-3 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aCHEMISTRY OF BIOCONJUGATES; CONTENTS; PREFACE; CONTRIBUTORS; SECTION I GENERAL METHODS OF BIOCONJUGATION; 1 COVALENT AND NONCOVALENT BIOCONJUGATION STRATEGIES; 1.1 INTRODUCTION; 1.2 COVALENT BIOCONJUGATION STRATEGIES; 1.2.1 Carboxyl Modifications; 1.2.2 Carbonyl Functional Groups; 1.2.3 Amine Modifications; 1.2.4 Thiol Modifications; 1.2.5 Hydroxyl Modifications; 1.2.6 Native Chemical Ligation and Expressed Protein Ligation; 1.2.7 Cross-linking Reagents for Bioconjugation; 1.2.8 Bioorthogonal Reactions; 1.2.9 Bioconjugation Via Transition Metal-catalyzed/Mediated Reactions 327 $a1.2.10 Other Covalent Bioconjugation Methods1.3 NONCOVALENT BIOCONJUGATION STRATEGIES; 1.3.1 Biotin-(Strept)Avidin System; 1.3.2 Electrostatic Interactions; 1.3.3 Metal-mediated Non-covalent Conjugation; 1.3.4 Hybridization Method; 1.4 CONCLUSIONS AND OUTLOOK; REFERENCES; SECTION II POLYMER BIOCONJUGATES; 2 BIOCONJUGATES BASED ON POLY(ETHYLENE GLYCOL)S AND POLYGLYCEROLS; 2.1 INTRODUCTION; 2.2 POLYETHYLENE GLYCOL-BASED BIOCONJUGATES; 2.2.1 PEG-protein Conjugates; 2.2.2 PEG-peptide Conjugates; 2.2.3 PEG-antibody Conjugates; 2.2.4 PEGylation of Cells and Tissues 327 $a2.2.5 PEG Conjugates of Oligonucleotides, Aptamers, and siRNAs2.2.6 PEG-drug Conjugates (PEG prodrugs); 2.2.7 PEGylation of Viruses; 2.3 LIMITATIONS OF PEG CONJUGATES; 2.4 POLYGLYCEROL-BASED CONJUGATES; 2.4.1 HPG-drug Conjugates; 2.4.2 HPG-peptide and Protein Conjugates; 2.4.3 HPG Glycoconjugates; 2.4.4 HPG-Red Blood Cell Conjugates for Antigen Protection; 2.5 CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; 3 SYNTHETIC POLYMER BIOCONJUGATE SYSTEMS; 3.1 INTRODUCTION; 3.2 PEPTIDE OR PROTEIN BIOCONJUGATION TECHNIQUES; 3.2.1 Conjugation with Amino Acid; 3.2.2 Conjugation with Peptide Chain 327 $a3.2.3 Conjugation with Proteins3.3 CARBOHYDRATE BIOCONJUGATION TECHNIQUES; 3.4 CONJUGATION WITH NUCLEIC ACID; 3.5 CONJUGATION WITH DRUGS; 3.6 CONJUGATION WITH CONTRAST AGENTS; 3.6.1 Polymers for Magnetic Resonance Imaging; 3.6.2 Polymers for Optical Imaging; 3.6.3 Polymers for Nuclear imaging; 3.7 CONCLUSION AND PERSPECTIVE; REFERENCES; 4 NATURAL POLYMER BIOCONJUGATE SYSTEMS; 4.1 INTRODUCTION; 4.2 NATURAL POLYMER SYSTEMS; 4.2.1 Protein-origin Polymer Bioconjugates; 4.2.2 Polysaccharidic Polymer Bioconjugates; 4.3 CONCLUSION AND FUTURE DIRECTIONS; ACKNOWLEDGMENT; REFERENCES 327 $a5 DENDRIMER BIOCONJUGATES: SYNTHESIS AND APPLICATIONS5.1 INTRODUCTION-DENDRIMERS FOR BIOCONJUGATE CHEMISTRY; 5.2 DENDRIMER-DRUG CONJUGATES; 5.2.1 Motivation for the Development of Dendrimer-Drug Conjugates; 5.2.2 Dendrimer-DOX Conjugates; 5.2.3 Dendrimer-MTX Conjugates; 5.2.4 Dendrimer-TAX Conjugates; 5.2.5 Dendrimer-NAC Conjugates; 5.2.6 Dendrimer-Sulfonic Acids; 5.3 DENDRIMER-CARBOHYDRATE CONJUGATES; 5.3.1 Motivation for the Development of Dendrimer-Carbohydrate Conjugates; 5.3.2 Dendrimer-Mannose Conjugates; 5.3.3 Dendrimer-Galactose Conjugates; 5.3.4 Dendrimer-AcNA Conjugates 327 $a5.4 DENDRIMER CONJUGATES WITH IMAGING AGENTS 330 $aThis book describes the chemistries involved in bioconjugation followed by an extensive review of all types of bioconjugates (polymers, dendrimers, nanoparticles, carbon nanotubes) reported in the literature for different bio-related applications. A section is devoted to the physico-chemical and biochemical properties of bioconjugates and implications in their uses. Finally, the book also provides a comprehensive account about the significance of bioconjugation - coverage that is lacking in many of the current resources available. 606 $aBioconjugates 615 0$aBioconjugates. 676 $a612.1/111 701 $aNarain$b Ravin$0963027 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910140188603321 996 $aChemistry of bioconjugates$92204985 997 $aUNINA