An introduction to statistics in early phase trials [[electronic resource] /] / Steven Julious, Say-Beng Tan, David Machin
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| Autore: |
Julious Steven A
|
| Titolo: |
An introduction to statistics in early phase trials [[electronic resource] /] / Steven Julious, Say-Beng Tan, David Machin
|
| Pubblicazione: | Chichester, West Sussex ; ; Hoboken, NJ, : John Wiley, 2010 |
| Descrizione fisica: | 1 online resource (271 p.) |
| Disciplina: | 610.15195 |
| 615/.19012 | |
| Soggetto topico: | Drugs - Testing - Statistical methods |
| Clinical trials - Statistical methods | |
| Altri autori: |
MachinDavid <1939->
TanSay Beng
|
| Note generali: | Description based upon print version of record. |
| Nota di bibliografia: | Includes bibliographical references and index. |
| Nota di contenuto: | An Introduction to Statistics in Early Phase Trials; Contents; Chapter 1 Early phase trials; Chapter 2 Introduction to pharmacokinetics; Chapter 3 Sample size calculations for clinical trials; Chapter 4 Crossover trial basics; Chapter 5 Multi-period crossover trials; Chapter 6 First time into man; Chapter 7 Bayesian and frequentist methods; Chapter 8 First-time-into-new-population studies; Chapter 9 Bioequivalence studies; Chapter 10 Other Phase I trials; Chapter 11 Phase II trials: general issues; Chapter 12 Dose-response studies; Chapter 13 Phase II trials with toxic therapies |
| Chapter 14 Interpreting and applying early phase trial resultsChapter 15 Go/No-Go criteria; Appendix; References; Index | |
| Sommario/riassunto: | All new medicines and devices undergo early phase trials to assess, interpret and better understand their efficacy, tolerability and safety. An Introduction to Statistics in Early Phase Trials describes the practical design and analysis of these important early phase clinical trials and provides the crucial statistical basis for their interpretation. It clearly and concisely provides an overview of the most common types of trials undertaken in early phase clinical research and explains the different methodologies used. The impact of statistical technologies on clinical development and t |
| Titolo autorizzato: | An introduction to statistics in early phase trials |
| ISBN: | 1-282-48277-7 |
| 9786612482779 | |
| 0-470-68616-2 | |
| 0-470-31917-8 | |
| Formato: | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione: | Inglese |
| Record Nr.: | 9910139509803321 |
| Lo trovi qui: | Univ. Federico II |
| Opac: | Controlla la disponibilità qui |