LEADER 03245nam 2200637Ia 450 001 9910139509803321 005 20200520144314.0 010 $a1-282-48277-7 010 $a9786612482779 010 $a0-470-68616-2 010 $a0-470-31917-8 035 $a(CKB)2550000000006555 035 $a(EBL)480423 035 $a(OCoLC)593295610 035 $a(SSID)ssj0000339296 035 $a(PQKBManifestationID)11274386 035 $a(PQKBTitleCode)TC0000339296 035 $a(PQKBWorkID)10324240 035 $a(PQKB)10422692 035 $a(MiAaPQ)EBC480423 035 $a(Au-PeEL)EBL480423 035 $a(CaPaEBR)ebr10361214 035 $a(CaONFJC)MIL248277 035 $a(PPN)22125644X 035 $a(EXLCZ)992550000000006555 100 $a20090814d2010 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 13$aAn introduction to statistics in early phase trials$b[electronic resource] /$fSteven Julious, Say-Beng Tan, David Machin 210 $aChichester, West Sussex ;$aHoboken, NJ $cJohn Wiley$d2010 215 $a1 online resource (271 p.) 300 $aDescription based upon print version of record. 311 $a0-470-05985-0 320 $aIncludes bibliographical references and index. 327 $aAn Introduction to Statistics in Early Phase Trials; Contents; Chapter 1 Early phase trials; Chapter 2 Introduction to pharmacokinetics; Chapter 3 Sample size calculations for clinical trials; Chapter 4 Crossover trial basics; Chapter 5 Multi-period crossover trials; Chapter 6 First time into man; Chapter 7 Bayesian and frequentist methods; Chapter 8 First-time-into-new-population studies; Chapter 9 Bioequivalence studies; Chapter 10 Other Phase I trials; Chapter 11 Phase II trials: general issues; Chapter 12 Dose-response studies; Chapter 13 Phase II trials with toxic therapies 327 $aChapter 14 Interpreting and applying early phase trial resultsChapter 15 Go/No-Go criteria; Appendix; References; Index 330 $aAll new medicines and devices undergo early phase trials to assess, interpret and better understand their efficacy, tolerability and safety. An Introduction to Statistics in Early Phase Trials describes the practical design and analysis of these important early phase clinical trials and provides the crucial statistical basis for their interpretation. It clearly and concisely provides an overview of the most common types of trials undertaken in early phase clinical research and explains the different methodologies used. The impact of statistical technologies on clinical development and t 606 $aDrugs$xTesting$xStatistical methods 606 $aClinical trials$xStatistical methods 615 0$aDrugs$xTesting$xStatistical methods. 615 0$aClinical trials$xStatistical methods. 676 $a610.15195 676 $a615/.19012 700 $aJulious$b Steven A$0886695 701 $aMachin$b David$f1939-$0520765 701 $aTan$b Say Beng$0886696 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910139509803321 996 $aAn introduction to statistics in early phase trials$91980094 997 $aUNINA LEADER 06545nam 2201621Ia 450 001 9910779412703321 005 20230803020352.0 010 $a1-299-40278-X 010 $a1-4008-4649-8 024 7 $a10.1515/9781400846498 035 $a(CKB)2550000001017850 035 $a(EBL)1131673 035 $a(OCoLC)837959342 035 $a(SSID)ssj0000860816 035 $a(PQKBManifestationID)12327577 035 $a(PQKBTitleCode)TC0000860816 035 $a(PQKBWorkID)10915537 035 $a(PQKB)10892350 035 $a(MiAaPQ)EBC1131673 035 $a(StDuBDS)EDZ0001059480 035 $a(MdBmJHUP)muse43354 035 $a(DE-B1597)453888 035 $a(OCoLC)979686148 035 $a(DE-B1597)9781400846498 035 $a(Au-PeEL)EBL1131673 035 $a(CaPaEBR)ebr10679138 035 $a(CaONFJC)MIL471528 035 $a(EXLCZ)992550000001017850 100 $a20121119d2013 uy 0 101 0 $aeng 135 $aurun#---|u||u 181 $ctxt 182 $cc 183 $acr 200 10$aSmall-town America$b[electronic resource] $efinding community, shaping the future /$fRobert Wuthnow 205 $aCourse Book 210 $aPrinceton, NJ $cPrinceton University Press$d2013 215 $a1 online resource (519 p.) 300 $aDescription based upon print version of record. 311 0 $a0-691-16582-3 311 0 $a0-691-15720-0 320 $aIncludes bibliographical references and index. 327 $tFront matter --$tContents --$tList of Figures --$tList of Profiles --$tPreface --$t1- Introduction --$t2- You Have to Deal with Everybody: The Inhabitants of Small Towns --$t3- Going to Be Buried Right Here: How Residents View Their Towns --$t4- Community Spirit: Small-Town Identities That Bind --$t5- The Frog Pond: Making Sense of Work and Money --$t6- Leadership: Earning Respect, Improving the Community --$t7- Habits of Faith: The Social Role of Small-Town Congregations --$t8- Contentious Issues: The Moral Sentiments of Community Life --$t9- Washington Is Broken: Politics and the New Populism --$t10- Keep Your Doors Open: Shaping the Future --$t11- Concluding Reflections: Community in Small Towns --$tAfterword --$tMethodology --$tNotes --$tSelected Bibliography --$tIndex 330 $aMore than thirty million Americans live in small, out-of-the-way places. Many of them could have joined the vast majority of Americans who live in cities and suburbs. They could live closer to more lucrative careers and convenient shopping, a wider range of educational opportunities, and more robust health care. But they have opted to live differently. In Small-Town America, we meet factory workers, shop owners, retirees, teachers, clergy, and mayors--residents who show neighborliness in small ways, but who also worry about everything from school closings and their children's futures to the ups and downs of the local economy. Drawing on more than seven hundred in-depth interviews in hundreds of towns across America and three decades of census data, Robert Wuthnow shows the fragility of community in small towns. He covers a host of topics, including the symbols and rituals of small-town life, the roles of formal and informal leaders, the social role of religious congregations, the perception of moral and economic decline, and the myriad ways residents in small towns make sense of their own lives. Wuthnow also tackles difficult issues such as class and race, abortion, homosexuality, and substance abuse. Small-Town America paints a rich panorama of individuals who reside in small communities, finding that, for many people, living in a small town is an important part of self-identity. 606 $aCities and towns$zUnited States 606 $aCommunities$zUnited States 610 $aRepublicans. 610 $aSuzanne Keller. 610 $aabortion. 610 $aagriculture. 610 $aantipathy. 610 $aathletics. 610 $abig government. 610 $abureaucracy. 610 $acareer opportunities. 610 $acaring. 610 $achildren. 610 $achurch closure. 610 $acivic responsibilities. 610 $aclass. 610 $acollege. 610 $acommunity life. 610 $acommunity spirit. 610 $acommunity ties. 610 $acommunity. 610 $acreationism. 610 $aeconomic decline. 610 $aeducation. 610 $aeducators. 610 $aemployment. 610 $aethnic diversity. 610 $aevolution. 610 $afamily. 610 $afrog-pond effect. 610 $afuture planning. 610 $agentry. 610 $agrassroots activism. 610 $ahigher education. 610 $ahomecoming festivals. 610 $ahomosexuality. 610 $aimmigration. 610 $ajob opportunities. 610 $aleaders. 610 $aleadership. 610 $aliving standards. 610 $aloyalty. 610 $amembership criteria. 610 $ametropolitan areas. 610 $amoney. 610 $amoral decline. 610 $anature. 610 $aneighborliness. 610 $aneighbors. 610 $aparents. 610 $apensioners. 610 $apolitics. 610 $apopulation decline. 610 $apopulism. 610 $apublic officials. 610 $aracial diversity. 610 $areligion. 610 $areligious buildings. 610 $areligious congregations. 610 $areligious organizations. 610 $areligious participation. 610 $arespect. 610 $aritual. 610 $aschool curriculum. 610 $aself-identity. 610 $aservice class. 610 $aslow pace. 610 $asmall towns. 610 $asmall-town life. 610 $asocial innovation. 610 $asocial networks. 610 $asocial strata. 610 $asocioeconomic status. 610 $astereotypes. 610 $asustainable energy. 610 $atechnology. 610 $aterritory. 610 $atownspeople. 610 $avoluntary organizations. 610 $awageworkers. 610 $awelfare. 610 $awork. 610 $ayoung people. 615 0$aCities and towns 615 0$aCommunities 676 $a307.760973 700 $aWuthnow$b Robert$0882687 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910779412703321 996 $aSmall-town America$93733745 997 $aUNINA