The Tight Junction and Its Proteins: More Than Just a Barrier : More Than Just a Barrier

• Autore: Fromm Michael
• Pubblicazione: Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020
• Descrizione fisica: 1 online resource (412 p.)
• Soggetto topico: Medicine
• Soggetto non controllato: actomyosin; adherens junction; adherens junctions; aging; AMP-activated protein kinase (AMPK); angubindin-1; angulin; anhidrosis; antibiotic-associated hemorrhagic colitis; antibody; antidiuretic hormone; apical junctional complex; apoptosis; aquaporin; arachnoid barrier; atopic dermatitis; atypical aPKCζ; barrier formation; barrier function; biliary epithelial cells; blood-biliary barrier; blood-brain barrier; blood-cerebrospinal fluid barrier; brain barriers; calcium permeability; Campylobacter jejuni; cancer; caspase; CaSR; celiac disease; cell growth; cell polarity; cell-cell contact; cerebral cavernous malformation; chemoresistance; cholangiocellular carcinoma; cholestasis; chronic liver disease; claudin; Claudin; claudin 1; claudin targeting; claudin-1; claudin-12; Claudin-14; claudin-2; claudin-5; Claudin-7; claudins; ClC-2; CLDN14; Clostridium perfringens enterotoxin; Clostridium perfringens iota-toxin; co-culture; cochlear implantation; collecting duct; curcumin; cytokines; disease; dorsal root ganglion; drinking rate; drug development; drug discovery; endometrial cancer; endothelia; endothelial barrier; enterocyte; enteropathogenic E. coli (EPEC); environmental sensors; epidermal barrier; epithelia; epithelial barrier; epithelial barrier dysfunction; epithelial fluid transport; epithelial sodium channel (ENaC), collecting duct cells; epithelial to mesenchymal transition; epithelium; EspF; fibrosis; gene transcription; gland dysfunction; glia limitans; hearing loss; HELIX syndrome; Hepatitis C Virus; hepatocellular carcinoma; human; hydrogen peroxide; hydrostatic pressure; hypermagnesemia; hypertrophy; hypokalemia; immune cells; in silico; inflammation; inflammatory bowel disease; interleukin 13; intestinal mucosa; intestine; ion channel; ion reabsorption; ion transport; ischemia; junctional adhesion molecule; kidney; kidney stones; Klebsiella oxytoca; lipolysis-stimulated lipoprotein receptor (LSR); liver; lung; MAGUK proteins; MDCK C7 cells; MEKK3; membrane proteins; metastasis; mice; migration; molecular dynamics; monocytes; mouse colon; mucosal immunology; mucus; mutations; Mz-ChA-1 cells; nephropathy; nerve injury; NES; neuropathic pain; neurovascular unit; NFκB; NHE2; NISCH syndrome; NLS; occludin; organ preservation; osmolality; osmoregulation; paracellular; paracellular barrier; paracellular channels and barriers; paracellular permeability; paracellular sodium transport; paracellular transport; paracellular water transport; pathogens; PDZ domain; permeability; phosphatidylcholine; phosphorylation; polarity; proliferation; protein domain; protein interactions; protein structure; proximal tubule; quercetin; reconstructed human epidermis; repair; retinal pigment epithelium; retinopathy; Rho; RhoA; ROCK; sensor; single molecule localization microscopy; skin; sorting nexin 9 (SNX9); STAT3; stem cell; stimulated emission depletion; structured illumination microscopy; super-resolution microscopy; thick ascending limb; tight epithelium; tight junction; tight junction assembly; tight junctions; tight junctions (TJ); tissue barrier; TNF; transepithelial electrical resistance (TER); transplantation; tricellular tight junction; tricellular tight junctions; tricellulin; tumor; tumor suppressor; UBE2Z; ubiquitin; vestibular function; viral entry; WNK4; ZO-1; ZO-2; zonula occludens
• Persona (resp. second.): KrugSusanne M; FrommMichael
• Sommario/riassunto: For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ-mainly the two families of claudins and TAMPs-several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue includes 43 articles covering numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, function and regulation by proteins of the tricellular TJ, TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJ as sensors and reacting to environmental conditions, and last but not least, TJ proteins and cancer.
• Altri titoli varianti: Tight Junction and Its Proteins
• Titolo autorizzato: The Tight Junction and Its Proteins
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910674057303321
• Lo trovi qui: Univ. Federico II