08331nam 2202713z- 450 991067405730332120210501(CKB)5400000000042655(oapen)https://directory.doabooks.org/handle/20.500.12854/69314(oapen)doab69314(EXLCZ)99540000000004265520202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierThe Tight Junction and Its Proteins: More Than Just a BarrierMore Than Just a BarrierBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (412 p.)3-03943-224-9 For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ-mainly the two families of claudins and TAMPs-several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue includes 43 articles covering numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, function and regulation by proteins of the tricellular TJ, TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJ as sensors and reacting to environmental conditions, and last but not least, TJ proteins and cancer.Tight Junction and Its ProteinsMedicinebicsscactomyosinadherens junctionadherens junctionsagingAMP-activated protein kinase (AMPK)angubindin-1angulinanhidrosisantibiotic-associated hemorrhagic colitisantibodyantidiuretic hormoneapical junctional complexapoptosisaquaporinarachnoid barrieratopic dermatitisatypical aPKCζbarrier formationbarrier functionbiliary epithelial cellsblood-biliary barrierblood-brain barrierblood-brain barrierblood-cerebrospinal fluid barrierbrain barrierscalcium permeabilityCampylobacter jejunicancercaspaseCaSRceliac diseasecell growthcell polaritycell-cell contactcerebral cavernous malformationchemoresistancecholangiocellular carcinomacholestasischronic liver diseaseclaudinClaudinclaudin 1claudin targetingclaudin-1claudin-12Claudin-14claudin-2claudin-5Claudin-7claudinsClC-2CLDN14Clostridium perfringens enterotoxinClostridium perfringens iota-toxinco-culturecochlear implantationcollecting ductcurcumincytokinesdiseasedorsal root gangliondrinking ratedrug developmentdrug discoveryendometrial cancerendotheliaendothelial barrierenterocyteenteropathogenic E. coli (EPEC)environmental sensorsepidermal barrierepitheliaepithelial barrierepithelial barrier dysfunctionepithelial fluid transportepithelial sodium channel (ENaC), collecting duct cellsepithelial to mesenchymal transitionepitheliumEspFfibrosisgene transcriptiongland dysfunctionglia limitanshearing lossHELIX syndromeHepatitis C Virushepatocellular carcinomahumanhydrogen peroxidehydrostatic pressurehypermagnesemiahypertrophyhypokalemiaimmune cellsin silicoinflammationinflammatory bowel diseaseinterleukin 13intestinal mucosaintestineion channelion reabsorptionion transportischemiajunctional adhesion moleculekidneykidney stonesKlebsiella oxytocalipolysis-stimulated lipoprotein receptor (LSR)liverlungMAGUK proteinsMDCK C7 cellsMEKK3membrane proteinsmetastasismicemigrationmolecular dynamicsmonocytesmouse colonmucosal immunologymucusmutationsMz-ChA-1 cellsnephropathynerve injuryNESneuropathic painneurovascular unitNFκBNHE2NISCH syndromeNLSoccludinorgan preservationosmolalityosmoregulationparacellularparacellular barrierparacellular channels and barriersparacellular permeabilityparacellular sodium transportparacellular transportparacellular water transportpathogensPDZ domainpermeabilityphosphatidylcholinephosphorylationpolarityproliferationprotein domainprotein interactionsprotein structureproximal tubulequercetinreconstructed human epidermisrepairretinal pigment epitheliumretinopathyRhoRhoAROCKsensorsingle molecule localization microscopyskinsorting nexin 9 (SNX9)STAT3stem cellstimulated emission depletionstructured illumination microscopysuper-resolution microscopythick ascending limbtight epitheliumtight junctiontight junction assemblytight junctionstight junctions (TJ)tissue barrierTNFtransepithelial electrical resistance (TER)transplantationtricellular tight junctiontricellular tight junctionstricellulintumortumor suppressorUBE2Zubiquitinvestibular functionviral entryWNK4ZO-1ZO-2zonula occludensMedicineFromm Michaeledt1287935Krug Susanne MedtFromm MichaelothKrug Susanne MothBOOK9910674057303321The Tight Junction and Its Proteins3020581UNINA