LEADER 08322nam 2202701z- 450 001 9910674057303321 005 20231214133536.0 035 $a(CKB)5400000000042655 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/69314 035 $a(EXLCZ)995400000000042655 100 $a20202105d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aThe Tight Junction and Its Proteins: More Than Just a Barrier$eMore Than Just a Barrier 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 electronic resource (412 p.) 311 $a3-03943-224-9 330 $aFor a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ?mainly the two families of claudins and TAMPs?several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue includes 43 articles covering numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, function and regulation by proteins of the tricellular TJ, TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJ as sensors and reacting to environmental conditions, and last but not least, TJ proteins and cancer. 517 $aTight Junction and Its Proteins 606 $aMedicine$2bicssc 610 $atissue barrier 610 $atight junction 610 $aclaudins 610 $atricellulin 610 $atight junctions 610 $aorgan preservation 610 $aintestine 610 $atransplantation 610 $aischemia 610 $aintestinal mucosa 610 $alung 610 $aepithelia 610 $ainterleukin 13 610 $aUBE2Z 610 $aubiquitin 610 $aosmolality 610 $ahydrostatic pressure 610 $acancer 610 $asensor 610 $atricellular tight junctions 610 $aendometrial cancer 610 $aepithelial barrier dysfunction 610 $aClaudin-7 610 $apermeability 610 $aWNK4 610 $aepithelial sodium channel (ENaC), collecting duct cells 610 $aclaudin-1 610 $ahydrogen peroxide 610 $aphosphorylation 610 $aclaudin 610 $aangulin 610 $adrug development 610 $aangubindin-1 610 $aClostridium perfringens enterotoxin 610 $aClostridium perfringens iota-toxin 610 $aantibody 610 $aMz-ChA-1 cells 610 $abiliary epithelial cells 610 $aphosphatidylcholine 610 $amucus 610 $aparacellular transport 610 $aatopic dermatitis 610 $acytokines 610 $aSTAT3 610 $aZO-2 610 $acholestasis 610 $agene transcription 610 $ahypertrophy 610 $atumor suppressor 610 $aNLS 610 $aNES 610 $aCaSR 610 $aRhoA 610 $abarrier function 610 $aparacellular permeability 610 $aantidiuretic hormone 610 $aClaudin-14 610 $aCLDN14 610 $ahearing loss 610 $avestibular function 610 $acochlear implantation 610 $aHepatitis C Virus 610 $aviral entry 610 $aepidermal barrier 610 $areconstructed human epidermis 610 $aclaudin targeting 610 $aCampylobacter jejuni 610 $acurcumin 610 $aapoptosis 610 $aco-culture 610 $amouse colon 610 $aTNF 610 $aNF?B 610 $alipolysis-stimulated lipoprotein receptor (LSR) 610 $aepithelial barrier 610 $acell?cell contact 610 $acaspase 610 $akidney stones 610 $aion reabsorption 610 $aquercetin 610 $abrain barriers 610 $ablood-brain barrier 610 $aneurovascular unit 610 $ablood-cerebrospinal fluid barrier 610 $aarachnoid barrier 610 $aglia limitans 610 $aadherens junctions 610 $aparacellular sodium transport 610 $athick ascending limb 610 $anephropathy 610 $aHELIX syndrome 610 $ahypokalemia 610 $ahypermagnesemia 610 $aanhidrosis 610 $agland dysfunction 610 $aaging 610 $ablood?brain barrier 610 $amutations 610 $akidney 610 $aliver 610 $askin 610 $ahuman 610 $amice 610 $adisease 610 $ain silico 610 $adrug discovery 610 $amembrane proteins 610 $aprotein interactions 610 $amolecular dynamics 610 $aantibiotic-associated hemorrhagic colitis 610 $aKlebsiella oxytoca 610 $atight junction assembly 610 $amonocytes 610 $aceliac disease 610 $aclaudin-2 610 $aepithelium 610 $ainflammation 610 $afibrosis 610 $aproliferation 610 $amigration 610 $atricellular tight junction 610 $aparacellular water transport 610 $atight epithelium 610 $aMDCK C7 cells 610 $acell growth 610 $aendothelia 610 $aadherens junction 610 $aapical junctional complex 610 $aAMP-activated protein kinase (AMPK) 610 $aparacellular barrier 610 $aprotein structure 610 $aprotein domain 610 $aoccludin 610 $ajunctional adhesion molecule 610 $azonula occludens 610 $aMAGUK proteins 610 $aPDZ domain 610 $astem cell 610 $achemoresistance 610 $aretinal pigment epithelium 610 $aretinopathy 610 $abarrier formation 610 $acollecting duct 610 $aclaudin-5 610 $aneuropathic pain 610 $anerve injury 610 $adorsal root ganglion 610 $aenteropathogenic E. coli (EPEC) 610 $atight junctions (TJ) 610 $apolarity 610 $aatypical aPKC? 610 $atransepithelial electrical resistance (TER) 610 $asorting nexin 9 (SNX9) 610 $aEspF 610 $aclaudin 1 610 $atumor 610 $ametastasis 610 $aepithelial to mesenchymal transition 610 $acerebral cavernous malformation 610 $aendothelial barrier 610 $aRho 610 $aROCK 610 $aMEKK3 610 $aion transport 610 $aion channel 610 $asuper-resolution microscopy 610 $astructured illumination microscopy 610 $astimulated emission depletion 610 $asingle molecule localization microscopy 610 $aClaudin 610 $ablood-biliary barrier 610 $achronic liver disease 610 $ahepatocellular carcinoma 610 $acholangiocellular carcinoma 610 $aNISCH syndrome 610 $arepair 610 $aNHE2 610 $aClC-2 610 $ainflammatory bowel disease 610 $amucosal immunology 610 $aZO-1 610 $aactomyosin 610 $aaquaporin 610 $adrinking rate 610 $aepithelial fluid transport 610 $aenterocyte 610 $aosmoregulation 610 $aparacellular 610 $aproximal tubule 610 $acalcium permeability 610 $aclaudin-12 610 $aparacellular channels and barriers 610 $acell polarity 610 $apathogens 610 $aimmune cells 610 $aenvironmental sensors 615 7$aMedicine 700 $aFromm$b Michael$4edt$01287935 702 $aKrug$b Susanne M$4edt 702 $aFromm$b Michael$4oth 702 $aKrug$b Susanne M$4oth 906 $aBOOK 912 $a9910674057303321 996 $aThe Tight Junction and Its Proteins$93020581 997 $aUNINA