Targeting Wnt Signaling in Cancer: Opportunities Abound If We Can Avoid the Sword of Damocles
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| Autore: |
Kahn Michael
|
| Titolo: |
Targeting Wnt Signaling in Cancer: Opportunities Abound If We Can Avoid the Sword of Damocles
|
| Pubblicazione: | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica: | 1 electronic resource (298 p.) |
| Soggetto topico: | Medicine |
| Pharmacology | |
| Soggetto non controllato: | Wnt signaling |
| synovial sarcoma | |
| TNIK | |
| NCB-0846 | |
| MYC | |
| hepatitis B virus | |
| HBV | |
| cancer | |
| liver cancer | |
| β-catenin | |
| TCF/LEF | |
| pancreatic cancer | |
| pancreatic stellate cells | |
| CBP | |
| p300 | |
| pancreatitis | |
| fibrosis | |
| just-right signaling | |
| APC | |
| colorectal cancer | |
| RNA-binding proteins | |
| Musashi | |
| drug discovery | |
| Notch signaling | |
| cancer therapy | |
| fungi secondary metabolite derivative | |
| microenvironment | |
| Wnt | |
| AML | |
| drug target | |
| signaling | |
| colorectal | |
| porcupine | |
| R-spondin | |
| serrated | |
| immunotherapy | |
| wnt | |
| vitamin D | |
| colon cancer | |
| L1 | |
| Wnt target genes | |
| cell adhesion | |
| NF-κB | |
| invasion and metastasis | |
| cancer stem cells | |
| EMT | |
| Lgr5 | |
| Wnt/beta-catenin signaling | |
| angiogenesis | |
| anti-angiogenic therapy | |
| gastrointestinal cancers | |
| therapeutic targeting of Wnt signaling | |
| β-catenin paradox | |
| molecular targeting | |
| urothelial cancer | |
| immune checkpoint inhibitor | |
| immunotherapy resistance | |
| IBD | |
| colitis | |
| β-catenin mutations | |
| tumor metabolism | |
| tumor immunology | |
| molecular therapeutics | |
| precision medicine | |
| astrocytic brain tumors | |
| DKKs | |
| GSK3β | |
| Persona (resp. second.): | LaiKeane |
| KahnMichael | |
| Sommario/riassunto: | Dysregulation of Wnt signaling is known to be associated with various cancers. As such, identification of novel Wnt pathway targets in cancer and better characterization of already-known targets present exciting, emerging opportunities for cancer treatment. In this Special Issue, we feature papers which discuss the role of Wnt signaling and associated targets in cancer metabolism, tumor immune response, and tumor microenvironment. Papers discussing a range of Wnt-mediated cancers, including those of the colon, liver, pancreas, synovium, bladder, etc., are included. |
| Altri titoli varianti: | Targeting Wnt Signaling in Cancer |
| Titolo autorizzato: | Targeting Wnt Signaling in Cancer: Opportunities Abound If We Can Avoid the Sword of Damocles |
| Formato: | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione: | Inglese |
| Record Nr.: | 9910566469503321 |
| Lo trovi qui: | Univ. Federico II |
| Opac: | Controlla la disponibilità qui |