New gold-catalyzed reactions and applications for the synthesis of alkaloids / / Ana Escribano Cuesta
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| Autore: |
Cuesta Ana Escribano
|
| Titolo: |
New gold-catalyzed reactions and applications for the synthesis of alkaloids / / Ana Escribano Cuesta
|
| Pubblicazione: | Cham ; ; New York, : Springer, c2013 |
| Edizione: | 1st ed. 2013. |
| Descrizione fisica: | 1 online resource (202 p.) |
| Disciplina: | 547 |
| Soggetto topico: | Catalysis |
| Alkynes | |
| Note generali: | Description based upon print version of record. |
| Nota di bibliografia: | Includes bibliographical references. |
| Nota di contenuto: | Introduction -- General Objectives -- Gold(I)-Catalyzed Reactions of 1,6-Enynes with Aldehydes: Cycloaddition versus Metathesis-Type Reactions -- Formation of Cyclobutene Compounds via Gold(I)-Catalyzed Cycloisomerization of 1,n-Enynes -- Approach Toward the Total Synthesis of Lundurines. |
| Sommario/riassunto: | Ana Escribano Cuesta's thesis presents a detailed study of the inter- and intramolecular reactions of carbonyl compounds with 1,6-enynes using gold (I) complexes. An important part of the work involved streamlining the variables that allow the selective synthesis of different products such as tricyclic compounds, dihydropyrans, 1,3-dienes or cyclobutenes. The second chapter highlights the importance and difficulties in synthesising a cyclobutene subunit and the author includes a detailed description of how the products were prepared. The final chapter outlines the synthesis of lundurines using methodology developed by the author's research group for intramolecular gold-catalyzed cyclization of indoles with alkynes. The lundurine products developed in this work show significant in vitro cytoxicity toward B16 melanoma cells. The work in this thesis has led to a number of publications in high-profile chemistry journals. |
| Titolo autorizzato: | New gold-catalyzed reactions and applications for the synthesis of alkaloids |
| ISBN: | 3-319-00702-5 |
| Formato: | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione: | Inglese |
| Record Nr.: | 9910437818103321 |
| Lo trovi qui: | Univ. Federico II |
| Opac: | Controlla la disponibilità qui |
Serie:
Springer Theses, Recognizing Outstanding Ph.D. Research, . 2190-5053