03015nam 2200589Ia 450 991043781810332120200520144314.03-319-00702-510.1007/978-3-319-00702-1(CKB)2670000000533722(EBL)1398585(OCoLC)858763910(SSID)ssj0000986802(PQKBManifestationID)11619259(PQKBTitleCode)TC0000986802(PQKBWorkID)10938296(PQKB)10343119(DE-He213)978-3-319-00702-1(MiAaPQ)EBC1398585(PPN)17242271X(EXLCZ)99267000000053372220130823d2013 uy 0engur|n|---|||||txtccrNew gold-catalyzed reactions and applications for the synthesis of alkaloids /Ana Escribano Cuesta1st ed. 2013.Cham ;New York Springerc20131 online resource (202 p.)Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053Description based upon print version of record.3-319-00701-7 3-319-03385-9 Includes bibliographical references.Introduction -- General Objectives -- Gold(I)-Catalyzed Reactions of 1,6-Enynes with Aldehydes: Cycloaddition versus Metathesis-Type Reactions -- Formation of Cyclobutene Compounds via Gold(I)-Catalyzed Cycloisomerization of 1,n-Enynes -- Approach Toward the Total Synthesis of Lundurines.Ana Escribano Cuesta's thesis presents a detailed study of the inter- and intramolecular reactions of carbonyl compounds with 1,6-enynes using gold (I) complexes. An important part of the work involved streamlining the variables that allow the selective synthesis of different products such as tricyclic compounds, dihydropyrans, 1,3-dienes or cyclobutenes. The second chapter highlights the importance and difficulties in synthesising a cyclobutene subunit and the author includes a detailed description of how the products were prepared. The final chapter outlines the synthesis of lundurines using methodology developed by the author's research group for intramolecular gold-catalyzed cyclization of indoles with alkynes. The lundurine products developed in this work show significant in vitro cytoxicity toward B16 melanoma cells. The work in this thesis has led to a number of publications in high-profile chemistry journals.Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053CatalysisAlkynesCatalysis.Alkynes.547Cuesta Ana Escribano1762172MiAaPQMiAaPQMiAaPQBOOK9910437818103321New gold-catalyzed reactions and applications for the synthesis of alkaloids4201951UNINA