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010   $a3-319-00702-5
024 7 $a10.1007/978-3-319-00702-1
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035   $a(EBL)1398585
035   $a(OCoLC)858763910
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035   $a(PQKBTitleCode)TC0000986802
035   $a(PQKBWorkID)10938296
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035   $a(DE-He213)978-3-319-00702-1
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100   $a20130823d2013      uy         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aNew gold-catalyzed reactions and applications for the synthesis of alkaloids /$fAna Escribano Cuesta
205   $a1st ed. 2013.
210   $aCham ;$aNew York $cSpringer$dc2013
215   $a1 online resource (202 p.)
225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053
300   $aDescription based upon print version of record.
311   $a3-319-00701-7 
311   $a3-319-03385-9 
320   $aIncludes bibliographical references.
327   $aIntroduction -- General Objectives -- Gold(I)-Catalyzed Reactions of 1,6-Enynes with Aldehydes: Cycloaddition versus Metathesis-Type Reactions -- Formation of Cyclobutene Compounds via Gold(I)-Catalyzed Cycloisomerization of 1,n-Enynes -- Approach Toward the Total Synthesis of Lundurines.
330   $aAna Escribano Cuesta's thesis presents a detailed study of the inter- and intramolecular reactions of carbonyl compounds with 1,6-enynes using gold (I) complexes. An important part of the work involved streamlining the variables that allow the selective synthesis of different products such as tricyclic compounds, dihydropyrans, 1,3-dienes or cyclobutenes. The second chapter highlights the importance and difficulties in synthesising a cyclobutene subunit and the author includes a detailed description of how the products were prepared. The final chapter outlines the synthesis of lundurines using methodology developed by the author's research group for intramolecular gold-catalyzed cyclization of indoles with alkynes. The lundurine products developed in this work show significant in vitro cytoxicity toward B16 melanoma cells. The work in this thesis has led to a number of publications in high-profile chemistry journals.
410  0$aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053
606   $aCatalysis
606   $aAlkynes
615  0$aCatalysis.
615  0$aAlkynes.
676   $a547
700   $aCuesta$b Ana Escribano$01762172
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910437818103321
996   $aNew gold-catalyzed reactions and applications for the synthesis of alkaloids$94201951
997   $aUNINA