DNA deamination and the immune system [[electronic resource] ] : AID in health and disease / / editors, Sebastian Fugmann, Marilyn Diaz, Nina Papavasiliou
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| Titolo: |
DNA deamination and the immune system [[electronic resource] ] : AID in health and disease / / editors, Sebastian Fugmann, Marilyn Diaz, Nina Papavasiliou
|
| Pubblicazione: | London, : Imperial College Press, 2011 |
| Descrizione fisica: | 1 online resource (232 p.) |
| Disciplina: | 571.967 |
| Soggetto topico: | DNA |
| Immune system | |
| Altri autori: |
FugmannSebastian
DiazMarilyn
PapavasiliouNina
|
| Note generali: | Description based upon print version of record. |
| Nota di bibliografia: | Includes bibliographical references and index. |
| Nota di contenuto: | Preface; Contents; List of Tables; List of Figures; Chapter 1 Introduction; Chapter 2 Switch Regions, ChromatinAccessibility and AID Targeting; Chapter 3 Cis-Regulatory Elements that Target AID to Immunoglobulin Loci; Chapter 4 Partners in Diversity: The Search for AID Co-Factors; Chapter 5 Resolution of AID Lesions in Class Switch Recombination; Chapter 6 Error-Prone and Error-Free Resolution of AID Lesions in SHM; Chapter 7 Regulatory Mechanisms of AID Function; Chapter 8 AID in Immunodeficiency and Cancer; Chapter 9 AID in Aging and in Autoimmune Disease; Index |
| Sommario/riassunto: | This book covers the current understanding of the role of activation-induced cytidine deaminase (AID) in the generation of antibody response to antigenic challenge. Since the discovery of AID, and the genetic demonstration of its role in somatic hypermutation and class-switch recombination of antibody genes, much has been learned about the biochemistry of this enzyme. However, some key questions remain hotly contested, such as: how does this enzyme get to the antibody locus leaving the rest of the genome intact, and why are DNA repair pathways which normally repair deamination events co-opted |
| Titolo autorizzato: | DNA deamination and the immune system |
| ISBN: | 1-283-14344-5 |
| 9786613143440 | |
| 1-84816-593-5 | |
| Formato: | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione: | Inglese |
| Record Nr.: | 9910789405503321 |
| Lo trovi qui: | Univ. Federico II |
| Opac: | Controlla la disponibilità qui |
Serie:
Molecular medicine and medicinal chemistry ; ; v. 3.