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[null,"1.","Record Nr.",null,"UNINA9910789405503321"]
[null,null,"Titolo",null,"DNA deamination and the immune system [[electronic resource] ] : AID in health and disease / / editors, Sebastian Fugmann, Marilyn Diaz, Nina Papavasiliou"]
[null,null,"Pubbl/distr/stampa",null,"London, : Imperial College Press, 2011"]
[null,null,"ISBN",null,"1-283-14344-5"]
[{"$nulls":4},"9786613143440"]
[{"$nulls":4},"1-84816-593-5"]
[null,null,"Descrizione fisica",null,"1 online resource (232 p.)"]
[null,null,"Collana",null,"Molecular medicine and medicinal chemistry ; ; v. 3"]
[null,null,"Disciplina",null,"571.967"]
[null,null,"Soggetti",null,"DNA"]
[{"$nulls":4},"Immune system"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Preface; Contents; List of Tables; List of Figures; Chapter 1 Introduction; Chapter 2 Switch Regions, ChromatinAccessibility and AID Targeting; Chapter 3 Cis-Regulatory Elements that Target AID to Immunoglobulin Loci; Chapter 4 Partners in Diversity: The Search for AID Co-Factors; Chapter 5 Resolution of AID Lesions in Class Switch Recombination; Chapter 6 Error-Prone and Error-Free Resolution of AID Lesions in SHM; Chapter 7 Regulatory Mechanisms of AID Function; Chapter 8 AID in Immunodeficiency and Cancer; Chapter 9 AID in Aging and in Autoimmune Disease; Index"]
[null,null,null,"Sommario/riassunto","This book covers the current understanding of the role of activation-induced cytidine deaminase (AID) in the generation of antibody response to antigenic challenge. Since the discovery of AID, and the genetic demonstration of its role in somatic hypermutation and class-switch recombination of antibody genes, much has been learned about the biochemistry of this enzyme. However, some key questions remain hotly contested, such as: how does this enzyme get to the antibody locus leaving the rest of the genome intact, and why are DNA repair pathways which normally repair deamination events co-opted"]