03065nam 2200625 a 450 991078940550332120230725031524.01-283-14344-597866131434401-84816-593-5(CKB)2670000000095737(EBL)731089(OCoLC)738433271(SSID)ssj0000522091(PQKBManifestationID)12205256(PQKBTitleCode)TC0000522091(PQKBWorkID)10522821(PQKB)10196654(MiAaPQ)EBC731089(WSP)0000P729(Au-PeEL)EBL731089(CaPaEBR)ebr10480223(CaONFJC)MIL314344(EXLCZ)99267000000009573720110714d2011 uy 0engur|n|---|||||txtccrDNA deamination and the immune system[electronic resource] AID in health and disease /editors, Sebastian Fugmann, Marilyn Diaz, Nina PapavasiliouLondon Imperial College Press20111 online resource (232 p.)Molecular medicine and medicinal chemistry ;v. 3Description based upon print version of record.1-84816-592-7 Includes bibliographical references and index.Preface; Contents; List of Tables; List of Figures; Chapter 1 Introduction; Chapter 2 Switch Regions, ChromatinAccessibility and AID Targeting; Chapter 3 Cis-Regulatory Elements that Target AID to Immunoglobulin Loci; Chapter 4 Partners in Diversity: The Search for AID Co-Factors; Chapter 5 Resolution of AID Lesions in Class Switch Recombination; Chapter 6 Error-Prone and Error-Free Resolution of AID Lesions in SHM; Chapter 7 Regulatory Mechanisms of AID Function; Chapter 8 AID in Immunodeficiency and Cancer; Chapter 9 AID in Aging and in Autoimmune Disease; IndexThis book covers the current understanding of the role of activation-induced cytidine deaminase (AID) in the generation of antibody response to antigenic challenge. Since the discovery of AID, and the genetic demonstration of its role in somatic hypermutation and class-switch recombination of antibody genes, much has been learned about the biochemistry of this enzyme. However, some key questions remain hotly contested, such as: how does this enzyme get to the antibody locus leaving the rest of the genome intact, and why are DNA repair pathways which normally repair deamination events co-opted Molecular medicine and medicinal chemistry ;v. 3.DNAImmune systemDNA.Immune system.571.967Fugmann Sebastian1487342Diaz Marilyn1487343Papavasiliou Nina1487344MiAaPQMiAaPQMiAaPQBOOK9910789405503321DNA deamination and the immune system3707139UNINA03351nam 2200769Ia 450 991078180570332120230721032342.00-8166-9870-8(CKB)1000000000488201(EBL)340769(OCoLC)476156613(SSID)ssj0000146178(PQKBManifestationID)11137356(PQKBTitleCode)TC0000146178(PQKBWorkID)10183054(PQKB)11667520(MiAaPQ)EBC340769(OCoLC)229033891(MdBmJHUP)muse39127(Au-PeEL)EBL340769(CaPaEBR)ebr10225515(CaONFJC)MIL522461(EXLCZ)99100000000048820120061211d2007 ub 0engur|n|---|||||txtccrEmpire islands[electronic resource] castaways, cannibals, and fantasies of conquest /Rebecca Weaver-HightowerMinneapolis University of Minnesota Press20071 online resource (310 p.)Description based upon print version of record.0-8166-4863-8 0-8166-4862-X Includes bibliographical references and index.Monarchs of all they survey -- Disciplined islands : white fatherhood, homosocial masculinity, and law -- Voracious cannibals, rapacious pirates, and threats of counterincorporation -- "Falling to the lowest degree of brutishness" : wild men, monsters, and the bestial taint -- Island parodies and Crusoe pantomimes : resistance from within -- The U.S. island fantasy, or cast away with Gilligan.Through a detailed unpacking of the castaway genre's appeal in English literature, Empire Islands forwards our understanding of the sociopsychology of British Empire. Rebecca Weaver-Hightower argues convincingly that by helping generations of readers to make sense of, and perhaps feel better about, imperial aggression, the castaway story in effect enabled the expansion and maintenance of European empire. Empire Islands asks why so many colonial authors chose islands as the setting for their storIslands in literatureEnglish fictionHistory and criticismEnglish fictionEnglish-speaking countriesHistory and criticismCastaways in literatureImperialism in literatureCannibalism in literaturePirates in literatureMonsters in literaturePsychology in literaturePsychoanalysis and literatureIslands in literature.English fictionHistory and criticism.English fictionHistory and criticism.Castaways in literature.Imperialism in literature.Cannibalism in literature.Pirates in literature.Monsters in literature.Psychology in literature.Psychoanalysis and literature.823.009/32Weaver-Hightower Rebecca908591MiAaPQMiAaPQMiAaPQBOOK9910781805703321Empire islands3859697UNINA