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Autore: | El-Kattan Ayman F. |
Titolo: | Oral bioavailability assessment : basics and strategies for drug discovery and development / / Ayman F. El-Kattan |
Pubblicazione: | Hoboken, New Jersey : , : Wiley Blackwell, , 2017 |
©2017 | |
Descrizione fisica: | 1 online resource (455 pages) : illustrations |
Disciplina: | 615.1/9 |
Soggetto topico: | Dental pharmacology |
Nota di bibliografia: | Includes bibliographical references and index. |
Nota di contenuto: | Drug pharmacokinetics and toxicokinetics -- GIT anatomy and physiology and drug oral bioavailability : impact of species differences -- Drug routes of excretion -- Physicochemical and biopharmaceutical properties that affect drug absorption of compounds absorbed by passive diffusion -- Physicochemical and biopharmaceutical factors affecting hepatic/intestinal first pass effect -- Impact of intestinal efflux transporters on oral absorption -- Impact of influx transporters on drug -- Extended Clearance Classification System (ECCS) and its utility in predicting clearance rate determining step in drug discovery -- In vitro and in situ approaches to measure intestinal permeability and efflux transporters -- In silico approaches to predict intestinal permeability -- In vivo preclinical approaches to deconvolute the contribution of first pass effect from oral absorption -- In vitro approaches to assess haptic metabolism and first pass effect -- The utility of ECCS as a roadmap to improve oral bioavailability of new molecular entities : industrial perspective. |
Titolo autorizzato: | Oral bioavailability assessment |
ISBN: | 1-118-91693-X |
1-118-91694-8 | |
1-118-91692-1 | |
Formato: | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione: | Inglese |
Record Nr.: | 9910533954403321 |
Lo trovi qui: | Univ. Federico II |
Opac: | Controlla la disponibilità qui |