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1. |
Record Nr. |
UNINA9910533954403321 |
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Autore |
El-Kattan Ayman F. |
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Titolo |
Oral bioavailability assessment : basics and strategies for drug discovery and development / / Ayman F. El-Kattan |
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Pubbl/distr/stampa |
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Hoboken, New Jersey : , : Wiley Blackwell, , 2017 |
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©2017 |
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ISBN |
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1-118-91693-X |
1-118-91694-8 |
1-118-91692-1 |
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Descrizione fisica |
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1 online resource (455 pages) : illustrations |
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Collana |
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Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods |
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Disciplina |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Drug pharmacokinetics and toxicokinetics -- GIT anatomy and physiology and drug oral bioavailability : impact of species differences -- Drug routes of excretion -- Physicochemical and biopharmaceutical properties that affect drug absorption of compounds absorbed by passive diffusion -- Physicochemical and biopharmaceutical factors affecting hepatic/intestinal first pass effect -- Impact of intestinal efflux transporters on oral absorption -- Impact of influx transporters on drug -- Extended Clearance Classification System (ECCS) and its utility in predicting clearance rate determining step in drug discovery -- In vitro and in situ approaches to measure intestinal permeability and efflux transporters -- In silico approaches to predict intestinal permeability -- In vivo preclinical approaches to deconvolute the contribution of first pass effect from oral absorption -- In vitro approaches to assess haptic metabolism and first pass effect -- The utility of ECCS as a roadmap to improve oral bioavailability of new molecular entities : industrial perspective. |
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2. |
Record Nr. |
UNISALENTO991002365469707536 |
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Autore |
La Stella T., Enzo |
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Titolo |
Dalie, dedali e damigiane : dal nome proprio al nome comune : dizionario storico di deonomastica : vocaboli derivati da nomi propri, con le corrispondenti forme francesi, inglesi, spagnole e tedesche / di Enzo La Stella T |
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Pubbl/distr/stampa |
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Bologna : Zanichelli ; Firenze : Olschki, 1990 |
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ISBN |
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Descrizione fisica |
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Disciplina |
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Soggetti |
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Lingua italiana - Dizionari storici |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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